MicroRNA targeting by quercetin in cancer treatment and chemoprotection

Doo Hwan Kim; Haroon Khan; Hammad Ullah; Sherif T S Hassan; Karel Šmejkal; Thomas Efferth; Mohamad Fawzi Mahomoodally; Suowen Xu; Solomon Habtemariam; Rosanna Filosa; Ricardo Lagoa; Kannan Rr Rengasamy

doi:10.1016/j.phrs.2019.104346

MicroRNA targeting by quercetin in cancer treatment and chemoprotection

Pharmacol Res. 2019 Sep:147:104346. doi: 10.1016/j.phrs.2019.104346. Epub 2019 Jul 8.

Authors

Affiliations

¹ Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea.
² Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan. Electronic address: hkdr2006@gmail.com.
³ Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
⁴ Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic.
⁵ Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
⁶ Department of Health Sciences, Faculty of Science, University of Mauritius, 230, Réduit, Mauritius.
⁷ University of Rochester, Aab Cardiovascular Research Institute, Rochester, NY, 14623, USA.
⁸ Pharmacognosy Research Laboratories and Herbal Analysis Services UK, University of Greenwich, UK.
⁹ Institute of Food Sciences, National Research Council, Roma str. 64, Avellino, 83100, Italy; Consorzio Sannio Tech, AMP Biotec, Appia Str, Apollosa, Benevento, 82030, Italy.
¹⁰ School of Technology and Management, Polytechnic Institute of Leiria, Portugal; UCIBIO-Faculty of Science and Technology, University NOVA of Lisbon, Portugal. Electronic address: ricardo.lagoa@ipleiria.pt.
¹¹ Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea. Electronic address: Rengasamy@enzymeinhibitors.co.in.

PMID: 31295570
DOI: 10.1016/j.phrs.2019.104346

Abstract

A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health-promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.

Keywords: Bioinformatic tools; Cancer; Carcinogenesis; Chemoprevention; Epigenetic regulation; Flavonoids.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Antioxidants / pharmacology
Antioxidants / therapeutic use*
Biomarkers
Chemoprevention
Drug Discovery
Humans
MicroRNAs*
Neoplasms* / drug therapy
Neoplasms* / genetics
Neoplasms* / prevention & control
Quercetin / pharmacology
Quercetin / therapeutic use*

Substances

Antineoplastic Agents
Antioxidants
Biomarkers
MicroRNAs
Quercetin