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Assessment of Adiposity Distribution and Its Association With Diabetes and Insulin Resistance: A Population-Based Study

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Assessment of Adiposity Distribution and Its Association With Diabetes and Insulin Resistance: A Population-Based Study

Kan Sun et al. Diabetol Metab Syndr.

Abstract

Background: Rational measures in estimating adiposity distribution in diabetic patients has yet to be validated. This study aims to provide insight about the possible links between routinely available body adiposity parameters and the development of both diabetes and insulin resistance.

Methods: We performed a population-based cross-sectional study in 9496 subjects aged 40 years or older. All of the body adiposity measures including body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR), visceral adiposity index (VAI), body adiposity index (BAI) and lipid accumulation product index (LAP) were separately evaluated according to standard measurement methods. Diabetes was diagnosed according to the American Diabetes Association 2010 criteria.

Results: All tested body adiposity measurements were significantly associated with fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) 2 h glucose, HbA1c and fasting insulin. Compared with other adiposity phenotypes, LAP have shown the relatively strongest while BAI have shown the relatively weakest association with increased odds of both diabetes and insulin resistance across all logistic regression models. Additionally, LAP provided the best discrimination accuracy for diabetes [area under the curve (AUC): 0.658 95% confidence intervals (CI) 0.645-0.671] and insulin resistance (AUC: 0.781 95% CI 0.771-0.792) when compared with other body adiposity parameters.

Conclusions: The LAP index seems to be a better indicator than other adiposity measures tested in the study to evaluate the association of visceral fat mass with diabetes and insulin resistance, which should be given more consideration in the clinical practice.

Keywords: Body adiposity index; Body adiposity parameters; Diabetes; Insulin resistance; Lipid accumulation product index; Visceral adiposity index.

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of FPG, OGTT 2 h glucose and HbA1c stratified by quartiles of body adiposity parameters a FPG, b OGTT 2 h glucose, c HbA1c. The box plot: upper horizontal line of box, 75th percentile; lower horizontal line of box, 25th percentile; solid point within box, 50th percentile (the median); upper solid point outside box, 90th percentile; lower solid point outside box, 10th percentile
Fig. 2
Fig. 2
Prevalence of diabetes and insulin resistance in different quartiles of body adiposity parameters a diabetes, b insulin resistance

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References

    1. Bragg F, Holmes MV, Iona A, Guo Y, Du H, Chen Y, et al. Association between diabetes and cause-specific mortality in rural and urban areas of China. JAMA. 2017;317:280–289. doi: 10.1001/jama.2016.19720. - DOI - PMC - PubMed
    1. Emerging Risk Factors C. Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215–2222. doi: 10.1016/S0140-6736(10)60484-9. - DOI - PMC - PubMed
    1. Tobias DK, Pan A, Jackson CL, O’Reilly EJ, Ding EL, Willett WC, et al. Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med. 2014;370:233–244. doi: 10.1056/NEJMoa1304501. - DOI - PMC - PubMed
    1. Cornier MA, Despres JP, Davis N, Grossniklaus DA, Klein S, Lamarche B, et al. Assessing adiposity: a scientific statement from the American Heart Association. Circulation. 2011;124:1996–2019. doi: 10.1161/CIR.0b013e318233bc6a. - DOI - PubMed
    1. Du T, Yuan G, Zhang M, Zhou X, Sun X, Yu X. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovasc Diabetol. 2014;13:146. doi: 10.1186/s12933-014-0146-3. - DOI - PMC - PubMed

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