Management of neoplastic pericardial disease

Herz. 2020 Dec;45(Suppl 1):46-51. doi: 10.1007/s00059-019-4833-4. Epub 2019 Jul 11.


At present, there is no accurate and effective method for treating neoplastic pericardial effusion. This study analyzed the current literature on the treatment of neoplastic pericardial effusion to provide advice and guidance for clinical treatment. Surgical treatments include pericardial puncture, extension of catheter drainage, pericardial window, and surgical pericardiotomy. Each surgical procedure has a corresponding indication, and the best treatment is selected according to the patient's specific conditions. Systemic chemotherapy is effective in lymphoma and small cell lung cancer that are sensitive to chemotherapeutic drugs. Although pericardial injection of drugs is effective for pericardial tamponade and recurrent pericardial effusion, these methods can only temporarily relieve symptoms and cannot prolong the life of patients. In recent years, immunotherapy, especially adoptive immunotherapy, has achieved good results in the treatment of neoplastic pericardial effusion, thus providing a novel treatment option for neoplastic pericardial effusion.

Keywords: Cancer; Immunotherapy; Neoplastic pericardial disease; Pericardium; Treatment management.

Publication types

  • Review

MeSH terms

  • Cardiac Tamponade* / diagnosis
  • Cardiac Tamponade* / etiology
  • Cardiac Tamponade* / therapy
  • Disease*
  • Drainage
  • Humans
  • Neoplasms*
  • Pericardial Effusion* / etiology
  • Pericardial Effusion* / therapy
  • Pericardium / surgery