Senescence Evasion in Chemotherapy: A Sweet Spot for p21

Humza M Ashraf; Justin Moser; Sabrina L Spencer

doi:10.1016/j.cell.2019.06.025

Senescence Evasion in Chemotherapy: A Sweet Spot for p21

Cell. 2019 Jul 11;178(2):267-269. doi: 10.1016/j.cell.2019.06.025.

Authors

Humza M Ashraf¹, Justin Moser¹, Sabrina L Spencer²

Affiliations

¹ Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
² Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA. Electronic address: sabrina.spencer@colorado.edu.

Abstract

Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.

Publication types

Comment

MeSH terms

Cell Cycle
Cell Differentiation
Cell Proliferation
Cellular Senescence*
Cyclin-Dependent Kinase Inhibitor p21

Substances

Cyclin-Dependent Kinase Inhibitor p21

Abstract

Publication types

MeSH terms

Substances

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