Effective botulinum toxin injection guide for treatment of cervical dystonia

Clin Anat. 2020 Mar;33(2):192-198. doi: 10.1002/ca.23430. Epub 2019 Jul 25.

Abstract

The aim of this study was to elucidate the distribution of the accessory nerve within the sternocleidomastoid muscle (SCM) to aid identifying the optimum sites for botulinum neurotoxin (BoNT) injections and applying chemical neurolysis. Thirty SCM specimens from 15 Korean cadavers were used in this study. Sihler's staining was applied to 10 of the SCM specimens. Transverse lines were drawn in 20 sections to divide the SCM into 10 divisions vertically, and a vertical line was drawn into the medial and lateral halves from the mastoid process to the sternoclavicular joint. The most densely innervated areas were 5/10-6/10 and 6/10-7/10 along the lateral and medial parts of the muscle, respectively. We suggest injecting BoNT in the medial region 6/10-7/10 along the SCM prior to injecting in the lateral region 5/10-6/10 along the muscle to ensure safe and effective treatment. Clin. Anat. 33:192-198, 2020. © 2019 Wiley Periodicals, Inc.

Keywords: Sihler's stain; botulinum neurotoxin; cervical dystonia; intramuscular distribution; sternocleidomastoid muscle.

MeSH terms

  • Accessory Nerve / anatomy & histology*
  • Aged
  • Aged, 80 and over
  • Anatomic Landmarks
  • Botulinum Toxins, Type A / administration & dosage*
  • Cadaver
  • Dystonia / drug therapy*
  • Female
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Neck Muscles / anatomy & histology*
  • Neuromuscular Agents / administration & dosage
  • Torticollis / drug therapy*

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A