Impact of concomitant treatment of non-chronic total occlusion lesions at the time of chronic total occlusion intervention

Int J Cardiol. 2020 Jan 15;299:75-80. doi: 10.1016/j.ijcard.2019.06.077. Epub 2019 Jul 3.

Abstract

Background: During chronic total occlusion (CTO) percutaneous coronary intervention (PCI), sometimes non-CTO lesions are also treated.

Methods: We compared the clinical and procedural characteristics and outcomes of CTO PCIs with and without concomitant treatment of a non-CTO lesion in a contemporary multicenter CTO registry.

Results: Of the 3598 CTO PCIs performed at 21 centers between 2012 and 2018, 814 (23%) also included PCI of at least one non-CTO lesion. Patients in whom non-CTO lesions were treated were older (65 ± 10 vs. 64 ± 10 years, p = 0.03), more likely to present with an acute coronary syndrome (32% vs. 23%, p < 0.01), and less likely to undergo PCI of a right coronary artery (RCA) CTO (46% vs. 58%, p < 0.01). The most common non-CTO lesion location was the left anterior descending artery (31%), followed by the circumflex (29%) and the RCA (25%).Combined non-CTO and CTO-PCI procedures had similar technical (88% vs. 87%, p = 0.33) and procedural (85% vs. 85%, p = 0.74) success and major in-hospital complication rates (3.4% vs. 2.7%, p = 0.23), but had longer procedure duration (131 [88, 201] vs. 117 [75, 179] minutes, p < 0.01), higher patient air kerma radiation dose (3.0 [1.9, 4.8] vs. 2.8 [1.5, 4.6] Gray, p < 0.01) and larger contrast volume (300 [220, 380] vs. 250 [180, 350] ml, p < 0.01).

Conclusions: Combined CTO PCI with PCI of non-CTO lesions is associated with similar success and major in-hospital complication rates compared with cases in which only CTOs were treated, but requires longer procedure duration and higher radiation dose and contrast volume.

Keywords: Chronic total occlusions; Percutaneous coronary interventions.

Publication types

  • Multicenter Study

MeSH terms

  • Acute Coronary Syndrome* / diagnosis
  • Acute Coronary Syndrome* / etiology
  • Acute Disease
  • Age Factors
  • Chronic Disease
  • Coronary Angiography / methods
  • Coronary Occlusion* / diagnosis
  • Coronary Occlusion* / physiopathology
  • Coronary Occlusion* / surgery
  • Coronary Vessels* / diagnostic imaging
  • Coronary Vessels* / pathology
  • Coronary Vessels* / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Operative Time
  • Outcome Assessment, Health Care
  • Percutaneous Coronary Intervention* / adverse effects
  • Percutaneous Coronary Intervention* / methods
  • Postoperative Complications* / diagnosis
  • Postoperative Complications* / etiology
  • Radiation Dosage
  • Registries / statistics & numerical data
  • Risk Assessment
  • Risk Factors