Synergistic activation of human T cells by interleukin 1 and interleukin 6

Eur J Immunol. 1988 Apr;18(4):653-6. doi: 10.1002/eji.1830180427.


Purified human interleukin 6 (IL 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting T cells subliminally activated with phytohemagglutinin (PHA). This response seemed independent of IL 2 but highly dependent on the presence of accessory cells. Indeed, when accessory cell-depleted tonsillar T cells were activated with PHA and exposed to IL 6, only minimal proliferations were observed. A similar result was obtained with IL 1. However, a combination of these two cytokines induced strong proliferations, indicating that IL 1 and IL 6 plays a synergistic role in the interactions between accessory cells and T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Presenting Cells / immunology
  • Drug Synergism
  • Growth Substances
  • Humans
  • Interleukin-1 / administration & dosage*
  • Interleukin-6
  • Interleukins / administration & dosage*
  • Lymphocyte Activation / drug effects*
  • Receptors, Immunologic / physiology
  • Receptors, Interleukin-2
  • T-Lymphocytes / immunology*


  • Growth Substances
  • Interleukin-1
  • Interleukin-6
  • Interleukins
  • Receptors, Immunologic
  • Receptors, Interleukin-2