Distinct subdivisions of human medial parietal cortex support recollection of people and places

Elife. 2019 Jul 15;8:e47391. doi: 10.7554/eLife.47391.

Abstract

Human medial parietal cortex (MPC) is implicated in multiple cognitive processes including memory recall, visual scene processing and navigation, and is a core component of the default mode network. Here, we demonstrate distinct subdivisions of MPC that are selectively recruited during memory recall of either specific people or places. First, distinct regions of MPC exhibited differential functional connectivity with medial and lateral regions of ventral temporal cortex (VTC). Second, these same medial regions showed selective, but negative, responses to the visual presentation of different stimulus categories, with clear preferences for scenes and faces. Finally, and most critically, these regions were differentially recruited during memory recall of either people or places with a strong familiarity advantage. Taken together, these data suggest that the organizing principle defining the medial-lateral axis of VTC is reflected in MPC, but in the context of memory recall.

Keywords: fMRI; human; medial parietal cortex; memory; neuroscience; vision.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Mental Recall / physiology*
  • Nerve Net / physiology
  • Oxygen / blood
  • Parietal Lobe / physiology*
  • Photic Stimulation
  • Rest
  • Temporal Lobe / physiology

Substances

  • Oxygen