Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada

doi:10.1001/jamainternmed.2019.1859

. 2019 Oct 1;179(10):1434-1436.

doi: 10.1001/jamainternmed.2019.1859.

Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada

William K Silverstein¹, Yulia Lin^{1

2

3

4}, Christoffer Dharma⁵, Ruth Croxford⁵, Craig C Earle^{1

2

5}, Matthew C Cheung^{1

2

5}

Affiliations

¹ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Division of Medical Oncology & Hematology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
³ Department of Laboratory Medicine & Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁴ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁵ ICES, Toronto, Ontario, Canada.

PMID: 31305876
PMCID: PMC6632124
DOI: 10.1001/jamainternmed.2019.1859

Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada

William K Silverstein et al. JAMA Intern Med. 2019.

. 2019 Oct 1;179(10):1434-1436.

doi: 10.1001/jamainternmed.2019.1859.

Authors

William K Silverstein¹, Yulia Lin^{1

2

3

4}, Christoffer Dharma⁵, Ruth Croxford⁵, Craig C Earle^{1

2

5}, Matthew C Cheung^{1

2

5}

Affiliations

¹ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Division of Medical Oncology & Hematology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
³ Department of Laboratory Medicine & Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁴ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁵ ICES, Toronto, Ontario, Canada.

PMID: 31305876
PMCID: PMC6632124
DOI: 10.1001/jamainternmed.2019.1859

Erratum in

Error in Dates of Data Analysis in the Methods.
[No authors listed] [No authors listed] JAMA Intern Med. 2019 Oct 1;179(10):1448. doi: 10.1001/jamainternmed.2019.3987. JAMA Intern Med. 2019. PMID: 31449294 Free PMC article. No abstract available.

Abstract

This population-based cohort study evaluated how often intramuscular vitamin B₁₂ was prescribed to Canadian elderly patients when not medically necessary.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Lin reported that she was a consultant for Pfizer and that she was on the advisory board of Amgen. No other disclosures were reported.

Figures

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Comment in

Vitamin B12 Therapy in Older Adults and Misconception of Its Inappropriateness.
Arendt JFH, Nexo E. Arendt JFH, et al. JAMA Intern Med. 2019 Nov 1;179(11):1605. doi: 10.1001/jamainternmed.2019.4899. JAMA Intern Med. 2019. PMID: 31682696 No abstract available.
Vitamin B12 Therapy in Older Adults and Misconception of Its Inappropriateness.
Stall NM, Goldlist BJ, Alibhai SMH. Stall NM, et al. JAMA Intern Med. 2019 Nov 1;179(11):1606. doi: 10.1001/jamainternmed.2019.4926. JAMA Intern Med. 2019. PMID: 31682697 No abstract available.
Vitamin B12 Therapy in Older Adults and Misconception of Its Inappropriateness-Reply.
Silverstein WK, Lin Y, Cheung MC. Silverstein WK, et al. JAMA Intern Med. 2019 Nov 1;179(11):1606-1607. doi: 10.1001/jamainternmed.2019.4902. JAMA Intern Med. 2019. PMID: 31682704 No abstract available.

Cited by

Vitamin B₁₂ deficiency.
Silverstein WK, Cheung MC, Lin Y. Silverstein WK, et al. CMAJ. 2022 Jun 20;194(24):E843. doi: 10.1503/cmaj.220306. CMAJ. 2022. PMID: 35724997 Free PMC article. No abstract available.
Prescription Rates, Polypharmacy and Prescriber Variability in Swiss General Practice-A Cross-Sectional Database Study.
Rachamin Y, Jäger L, Meier R, Grischott T, Senn O, Burgstaller JM, Markun S. Rachamin Y, et al. Front Pharmacol. 2022 Feb 14;13:832994. doi: 10.3389/fphar.2022.832994. eCollection 2022. Front Pharmacol. 2022. PMID: 35237170 Free PMC article.
Testing and Prescribing Vitamin B12 in Swiss General Practice: A Survey among Physicians.
Bardheci K, Jäger L, Risch L, Rosemann T, Burgstaller JM, Markun S. Bardheci K, et al. Nutrients. 2021 Jul 29;13(8):2610. doi: 10.3390/nu13082610. Nutrients. 2021. PMID: 34444770 Free PMC article.
Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JM. Markun S, et al. Nutrients. 2021 Mar 12;13(3):923. doi: 10.3390/nu13030923. Nutrients. 2021. PMID: 33809274 Free PMC article.
Physician Factors Associated with Inappropriate Vitamin B12 Prescribing in Ontario, Canada.
Silverstein WK, Lin Y, Dharma C, Croxford R, Cheung MC. Silverstein WK, et al. J Gen Intern Med. 2021 Sep;36(9):2888-2890. doi: 10.1007/s11606-020-06185-3. Epub 2020 Sep 9. J Gen Intern Med. 2021. PMID: 32909232 Free PMC article. No abstract available.

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References

1. Chan CQH, Low LL, Lee KH. Oral vitamin B12 replacement for the treatment of pernicious anemia. Front Med (Lausanne). 2016;3(38):38. - PMC - PubMed
1. van Walraven CG, Naylor CD. Use of vitamin B12 injections among elderly patients by primary care practitioners in Ontario. CMAJ. 1999;161(2):146-149. - PMC - PubMed
1. Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL. Oral cobalamin remains medicine’s best kept secret. Arch Gerontol Geriatr. 2007;44(1):49-59. doi:10.1016/j.archger.2006.02.003 - DOI - PubMed
1. Tilburt JC, Wynia MK, Sheeler RD, et al. . Views of US physicians about controlling health care costs. JAMA. 2013;310(4):380-388. doi:10.1001/jama.2013.8278 - DOI - PMC - PubMed
1. Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology . Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-513. doi:10.1111/bjh.12959 - DOI - PubMed

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[1] Chan CQH, Low LL, Lee KH. Oral vitamin B12 replacement for the treatment of pernicious anemia. Front Med (Lausanne). 2016;3(38):38. - PMC - PubMed

[2] Chan CQH, Low LL, Lee KH. Oral vitamin B12 replacement for the treatment of pernicious anemia. Front Med (Lausanne). 2016;3(38):38. - PMC - PubMed

[3] van Walraven CG, Naylor CD. Use of vitamin B12 injections among elderly patients by primary care practitioners in Ontario. CMAJ. 1999;161(2):146-149. - PMC - PubMed

[4] van Walraven CG, Naylor CD. Use of vitamin B12 injections among elderly patients by primary care practitioners in Ontario. CMAJ. 1999;161(2):146-149. - PMC - PubMed

[5] Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL. Oral cobalamin remains medicine’s best kept secret. Arch Gerontol Geriatr. 2007;44(1):49-59. doi:10.1016/j.archger.2006.02.003 - DOI - PubMed

[6] Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL. Oral cobalamin remains medicine’s best kept secret. Arch Gerontol Geriatr. 2007;44(1):49-59. doi:10.1016/j.archger.2006.02.003 - DOI - PubMed

[7] Tilburt JC, Wynia MK, Sheeler RD, et al. . Views of US physicians about controlling health care costs. JAMA. 2013;310(4):380-388. doi:10.1001/jama.2013.8278 - DOI - PMC - PubMed

[8] Tilburt JC, Wynia MK, Sheeler RD, et al. . Views of US physicians about controlling health care costs. JAMA. 2013;310(4):380-388. doi:10.1001/jama.2013.8278 - DOI - PMC - PubMed

[9] Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology . Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-513. doi:10.1111/bjh.12959 - DOI - PubMed

[10] Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology . Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-513. doi:10.1111/bjh.12959 - DOI - PubMed

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Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada

Affiliations

Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada

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