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Randomized Controlled Trial
, 13 (7), e0007581
eCollection

Clinical Evaluation for Morbidity Associated With Soil-Transmitted Helminth Infection in School-Age Children on Pemba Island, Tanzania

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Randomized Controlled Trial

Clinical Evaluation for Morbidity Associated With Soil-Transmitted Helminth Infection in School-Age Children on Pemba Island, Tanzania

Isaac I Bogoch et al. PLoS Negl Trop Dis.

Abstract

Background: More than 1.5 billion people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura), causing an estimated global burden in excess of 3 million disability-adjusted life years. However, the relationship between soil-transmitted helminth infection, adverse health consequences, and beneficial effects of deworming are not well understood.

Methodology: We pursued a detailed longitudinal clinical evaluation of school-age children to evaluate morbidity associated with soil-transmitted helminth infection and responses to treatment. This exploratory study was embedded into a randomized controlled trial. Overall, 434 children, aged 7-14 years, underwent a detailed medical history, physical examination, stool microscopy for soil-transmitted helminths, and hemoglobin (Hb) measurement at baseline. Medical history and stool examination were repeated at 3 and 18 weeks posttreatment. Additionally, Hb measurement was performed at the 18-week treatment follow-up. Logistic regression was employed to assess clinical factors associated with soil-transmitted helminth infection at baseline, and longitudinal data analysis to examine change in health outcomes following treatment over time.

Principal findings: All enrolled children were infected with T. trichiura, and randomized into four different treatment interventions. None of the medical history, physical examination, and laboratory (i.e., Hb) findings were associated with A. lumbricoides, hookworm, or S. stercoralis infection at baseline. A composite of physical exam findings for anemia, including pallor of the conjunctiva, nail beds, and palmar creases predicted lower Hb values (-3.8 g/dl, 95% confidence interval (CI): -6.9, -0.6 g/dl). When examining longitudinal trends, we did not find improvements to Hb or face Wong-Baker Likert scale among children with soil-transmitted helminth infection compared to those without infection, although there was a slight trend toward improving Hb values after treating hookworm infection.

Conclusions/significance: Our study demonstrates the challenges of measuring morbidity in the context of soil-transmitted helminth infection and treatment, thus confirming the mainly subtle morbidity effects of infection.

Conflict of interest statement

The authors have declared that no competing interests exist.

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References

    1. Pullan RL, Smith JL, Jasrasaria R, Brooker SJ. Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors. 2014; 7: 37 10.1186/1756-3305-7-37 - DOI - PMC - PubMed
    1. Jourdan PM, Lamberton PHL, Fenwick A, Addiss DG. Soil-transmitted helminth infections. Lancet. 2017; 391 (10117): 252–65. 10.1016/S0140-6736(17)31930-X - DOI - PubMed
    1. World Health Organization, 2006. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Geneva: World Health Organization; Pp. 1–62.
    1. Lo NC, Bogoch II, Blackburn BG, Raso G, N'Goran EK, Coulibaly JT, et al. Comparison of community-wide, integrated mass drug administration strategies for schistosomiasis and soil-transmitted helminthiasis: a cost-effectiveness modelling study. Lancet Glob Health. 2015; 3 (10): e629–38. 10.1016/S2214-109X(15)00047-9 - DOI - PubMed
    1. Jia TW, Melville S, Utzinger J, King CH, Zhou XN. Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2012; 6 (5): e1621 10.1371/journal.pntd.0001621 - DOI - PMC - PubMed

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Grant support

IIB was supported by a grant from the MSH UHN AMO Innovation Fund. The clinical trial was supported by the Medicor Foundation and the Swiss National Science Foundation (SNSF; Bern, Switzerland; grant number: 320030_14930). The funders played no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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