Effects of a hypoenergetic diet associated with açaí (Euterpe oleracea Mart.) pulp consumption on antioxidant status, oxidative stress and inflammatory biomarkers in overweight, dyslipidemic individuals

Clin Nutr. 2020 May;39(5):1464-1469. doi: 10.1016/j.clnu.2019.06.008. Epub 2019 Jun 12.


Objective: To evaluate the effects of a hypoenergetic diet (HD)associated with açaí pulp consumption on oxidative stress, antioxidant status and inflammatory biomarkers in overweight, dyslipidemic individuals.

Research methods & procedures: A randomized, double-blind, placebo-controlled clinical trial was conducted for 90 days. The study began with a 30-day run-in period, during which the intervention was exclusively a HD. Following this period, volunteers were randomized into 2 groups, and 200 g of either açaí pulp or placebo were added to the HD for 60 days. Anthropometric measurements, arterial pressure, oxidative stress and antioxidant status biomarkers, inflammatory and biochemical biomarkers were evaluated.

Results: Sixty-nine volunteers completed the clinical trial, 30 of which were in the HD + açaí group and 39 in HD + placebo group. Plasma 8-isoprostane concentrations significantly reduced 60 days after the intervention in the açaí group (p = 0.000), and there was a significant difference between the groups (açaí versus placebo; p = 0.037). Regarding inflammatory status parameters, a significant reduction in IL-6 was observed in the HD + açaí group (p = 0.042), and IFN-γ decreased significantly in both groups, HD + açaí (p = 0.001) and HD + placebo (p = 0.008); there were, however, no differences between the groups. Lipid profile parameters and blood glucose levels did not show change, regardless of nutritional intervention.

Conclusion: The addition of açaí to a HD, for 60 days, reduced oxidative stress and improved inflammation in overweight, dyslipidemic individuals.

Keywords: Acai Berry; Dyslipidemia; Euterpe; Inflammation; Obesity; Oxidative stress.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / metabolism*
  • Biomarkers
  • Diet, Reducing*
  • Dinoprost / analogs & derivatives
  • Dinoprost / genetics
  • Dinoprost / metabolism
  • Double-Blind Method
  • Dyslipidemias
  • Energy Intake*
  • Euterpe*
  • Female
  • Gene Expression Regulation / drug effects
  • Humans
  • Inflammation / metabolism*
  • Interferon-gamma / genetics
  • Interferon-gamma / metabolism
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism
  • Male
  • Middle Aged
  • Overweight
  • Oxidative Stress


  • Antioxidants
  • Biomarkers
  • Interleukin-6
  • 8-epi-prostaglandin F2alpha
  • Interferon-gamma
  • Dinoprost