Sleep modulating agents

Younggi Choi; Brian K Raymer

doi:10.1016/j.bmcl.2019.06.043

Sleep modulating agents

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2025-2033. doi: 10.1016/j.bmcl.2019.06.043. Epub 2019 Jun 24.

Authors

Younggi Choi¹, Brian K Raymer²

Affiliations

¹ Discovery Chemistry, Alkermes, 852 Winter Street, Waltham, MA, United States.
² Discovery Research, Alkermes, 852 Winter Street, Waltham, MA, United States. Electronic address: brian.raymer@alkermes.com.

PMID: 31307886
DOI: 10.1016/j.bmcl.2019.06.043

Abstract

Sleep and wake are two fundamental states of human existence. Conditions such as insomnia and hypersomnia can have profound negative effects on human health. Many pharmacological interventions impacting sleep and wake are available or are under development. This brief digest surveys early approaches to sleep modulation and highlights recent developments in sleep modulating agents.

Keywords: Cataplexy; Hypersomnia; Insomnia; Narcolepsy; Sleep.

Publication types

Review

MeSH terms

Animals
Humans
Sleep / drug effects*
Sleep Aids, Pharmaceutical / pharmacokinetics
Sleep Aids, Pharmaceutical / therapeutic use*
Sleep Wake Disorders / drug therapy*
Wakefulness-Promoting Agents / pharmacokinetics
Wakefulness-Promoting Agents / therapeutic use*

Substances

Sleep Aids, Pharmaceutical
Wakefulness-Promoting Agents