Synergistic Combinations and Repurposed Antibiotics Active against the Pandrug-Resistant Klebsiella pneumoniae Nevada Strain

Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01374-19. doi: 10.1128/AAC.01374-19. Print 2019 Sep.
No abstract available

Keywords: NDM-1; antimicrobial resistance; apramycin; carbapenem-resistant Enterobacteriaceae; colistin; multidrug resistance; repurposed; spectinomycin; synergy.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Colistin / pharmacology*
  • Drug Combinations
  • Drug Repositioning
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Drug Synergism
  • Fluoroquinolones / pharmacology
  • Fusidic Acid / pharmacology
  • Gene Expression
  • Glycopeptides / pharmacology
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / growth & development
  • Klebsiella pneumoniae / isolation & purification
  • Lincosamides / pharmacology
  • Macrolides / pharmacology
  • Microbial Sensitivity Tests
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Drug Combinations
  • Fluoroquinolones
  • Glycopeptides
  • Lincosamides
  • Macrolides
  • beta-Lactams
  • Fusidic Acid
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Colistin