Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres

Mikrochim Acta. 2019 Jul 15;186(8):532. doi: 10.1007/s00604-019-3644-x.

Abstract

An electrochemical sensor is described for the determination of L-dopa (levodopa; 3,4-dihydroxyphenylalanine). An inkjet-printed carbon nanotube (IJPCNT) electrode was modified with manganese dioxide microspheres by drop-casting. They coating was characterized by field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and X-ray powder diffraction. The sensor, best operated at a working voltage of 0.3 V, has a linear response in the 0.1 to 10 μM L-dopa concentration range, a 54 nM detection limit, excellent reproducibility, repeatability and selectivity. The amperometric approach was applied to the determination of L-dopa in spiked biological fluids and displayed satisfactory accuracy and precision. Graphical abstract Schematic representation of an amperometric method for determination L-dopa. It is based on the use of inkjet-printed carbon nanotube electrode (IJPCNT) modified with manganese dioxide (MnO2).

Keywords: Amperometry; Cyclic voltammetry; Electrochemical sensor; Levodopa; Manganese dioxide; Point-of-care.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrochemical Techniques / methods*
  • Electrodes
  • Humans
  • Ink
  • Levodopa / analysis*
  • Levodopa / blood
  • Levodopa / urine
  • Limit of Detection
  • Manganese Compounds / chemistry
  • Microspheres*
  • Nanotubes, Carbon / chemistry*
  • Oxides / chemistry
  • Point-of-Care Systems
  • Reproducibility of Results

Substances

  • Manganese Compounds
  • Nanotubes, Carbon
  • Oxides
  • Levodopa
  • manganese dioxide