Disseminated Bacille Calmette-Guérin infection in a patient with severe combined immunodeficiency caused by JAK3 gene mutation

Meiyun Li; Zhuo Chen; Yunlu Zhu; Ji Chen

doi:10.1111/pde.13884

Disseminated Bacille Calmette-Guérin infection in a patient with severe combined immunodeficiency caused by JAK3 gene mutation

Pediatr Dermatol. 2019 Sep;36(5):672-676. doi: 10.1111/pde.13884. Epub 2019 Jul 16.

Authors

Meiyun Li¹, Zhuo Chen¹, Yunlu Zhu², Ji Chen¹

Affiliations

¹ Department of Dermatology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Department of Dermatopathology, Shanghai Skin Disease Hospital, Clinical School of Anhui Medical University, Shanghai, China.

PMID: 31309596
DOI: 10.1111/pde.13884

Abstract

Bacille Calmette-Guérin (BCG), a live attenuated vaccine prepared using Mycobacterium bovis, can prevent tuberculosis in children and is routinely administered to infants in China and many other countries. A serious complication following vaccination is disseminated BCG infection. The risk is greatly increased in patients with severe combined immunodeficiency disease (SCID), a syndrome characterized by deficiency of both humoral and cellular immunity. We report a case of disseminated BCG infection in an infant with SCID caused by two novel janus kinase 3 (JAK3) gene mutations.

Keywords: JAK3; Bacille Calmette-Guerin (BCG); mutation; severe combined immunodeficiency; vaccination.

Publication types

Case Reports

MeSH terms

Adjuvants, Immunologic / adverse effects*
BCG Vaccine / adverse effects*
Female
Humans
Infant
Janus Kinase 3 / genetics*
Mutation / genetics*
Mycobacterium bovis
Severe Combined Immunodeficiency / complications*
Severe Combined Immunodeficiency / genetics
Tuberculosis / etiology*

Substances

Adjuvants, Immunologic
BCG Vaccine
JAK3 protein, human
Janus Kinase 3