Cure of hemophilia A by orthotopic liver transplantation

Gastroenterology. 1988 Jul;95(1):192-4. doi: 10.1016/0016-5085(88)90310-1.


A patient with hemophilia A and transfusion-associated end-stage chronic liver disease underwent orthotopic liver transplantation. He had no requirement for exogenous factor VIII replacement during the 27 mo he survived. Although his hemophilia was cured, he had antibodies to the human immunodeficiency virus; ultimately he died of complications arising from acquired immunodeficiency syndrome. Liver transplantation for cirrhotic hemophiliacs can free them of the need for antihemophilic-factor therapy; however, application of this approach may be limited by the high prevalence of human immunodeficiency virus infection in multitransfused hemophiliacs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Factor VIII / analysis
  • Hemophilia A / blood*
  • Hemophilia A / complications
  • Hepatitis C / etiology
  • Hepatitis C / surgery*
  • Hepatitis, Viral, Human / surgery*
  • Humans
  • Liver Transplantation*
  • Male
  • Transfusion Reaction


  • Factor VIII