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Comment
. 2019 Jul 23;116(30):14797-14798.
doi: 10.1073/pnas.1821436116. Epub 2019 Jul 16.

Quasi-Mendelian Paternal Inheritance of Mitochondrial DNA: A Notorious Artifact, or Anticipated Behavior?

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Comment

Quasi-Mendelian Paternal Inheritance of Mitochondrial DNA: A Notorious Artifact, or Anticipated Behavior?

Sofia Annis et al. Proc Natl Acad Sci U S A. .
Free PMC article

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
As paternal mtDNA (A) is distributed among blastomeres not all of them receive a copy (B). Later germline is parted from soma (C) and then the sex of the germline is set (D). After birth (dotted line), somatic and male germline cells exert selection in favor of the paternal mtDNA haplotype, so that somatic cells and spermatozoa end up as a paternal/maternal mtDNA mosaic. This explains somatic heteroplasmy (E) and quasi-Mendelian inheritance (F), respectively. In the female germline, there is no selection for the paternal haplotype (9), so oocytes keep low and variable proportions of paternal mtDNA (G) (SN7.3.2).

Comment in

Comment on

  • Biparental Inheritance of Mitochondrial DNA in Humans.
    Luo S, Valencia CA, Zhang J, Lee NC, Slone J, Gui B, Wang X, Li Z, Dell S, Brown J, Chen SM, Chien YH, Hwu WL, Fan PC, Wong LJ, Atwal PS, Huang T. Luo S, et al. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13039-13044. doi: 10.1073/pnas.1810946115. Epub 2018 Nov 26. Proc Natl Acad Sci U S A. 2018. PMID: 30478036 Free PMC article.

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