Abstract
Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure-activity relationships and relevant preclinical properties have been comprehensively described.
Keywords:
anticancer agents; cancer; drug discovery; signaling pathways; thiazole; tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Apoptosis / drug effects
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Cyclin-Dependent Kinases / antagonists & inhibitors
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Cyclin-Dependent Kinases / metabolism
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Drug Discovery*
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ErbB Receptors / antagonists & inhibitors
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ErbB Receptors / metabolism
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Humans
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Phosphatidylinositol 3-Kinases / chemistry
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Phosphatidylinositol 3-Kinases / metabolism
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Structure-Activity Relationship
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Thiazoles / chemistry*
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Thiazoles / pharmacology
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Thiazoles / therapeutic use
Substances
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Antineoplastic Agents
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Thiazoles
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ErbB Receptors
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Cyclin-Dependent Kinases