Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

doi:10.1093/infdis/jiz152

Meta-Analysis

. 2020 Jan 14;221(3):356-366.

doi: 10.1093/infdis/jiz152.

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Sudhir Venkatesan¹, Puja R Myles¹, Kirsty J Bolton², Stella G Muthuri³, Tarig Al Khuwaitir⁴, Ashish P Anovadiya⁵, Eduardo Azziz-Baumgartner⁶, Tahar Bajjou⁷, Matteo Bassetti⁸, Bojana Beovic⁹, Barbara Bertisch¹⁰, Isabelle Bonmarin¹¹, Robert Booy¹², Victor H Borja-Aburto¹³, Heinz Burgmann¹⁴, Bin Cao¹⁵, Jordi Carratala¹⁶, Tserendorj Chinbayar¹⁷, Catia Cilloniz¹⁸, Justin T Denholm¹⁹, Samuel R Dominguez²⁰, Pericles A D Duarte²¹, Gal Dubnov-Raz²², Sergio Fanella²³, Zhancheng Gao²⁴, Patrick Gérardin^{25

26

27}, Maddalena Giannella^{28

29}, Sophie Gubbels³⁰, Jethro Herberg³¹, Anjarath Lorena Higuera Iglesias³², Peter H Hoeger³³, Xiao Yun Hu³⁴, Quazi T Islam³⁵, Mirela F Jiménez³⁶, Gerben Keijzers³⁷, Hossein Khalili³⁸, Gabriela Kusznierz³⁹, Ilija Kuzman⁴⁰, Eduard Langenegger⁴¹, Kamran B Lankarani⁴², Yee-Sin Leo⁴³, Romina P Libster^{44

45

46}, Rita Linko⁴⁷, Faris Madanat⁴⁸, Efstratios Maltezos⁴⁹, Abdullah Mamun⁵⁰, Toshie Manabe⁵¹, Gokhan Metan⁵², Auksė Mickiene⁵³, Dragan Mikić⁵⁴, Kristin G I Mohn^{55

56}, Maria E Oliva⁵⁷, Mehpare Ozkan⁵⁸, Dhruv Parekh⁵⁹, Mical Paul⁶⁰, Barbara A Rath⁶¹, Samir Refaey⁶², Alejandro H Rodríguez⁶³, Bunyamin Sertogullarindan⁶⁴, Joanna Skręt-Magierło⁶⁵, Ayper Somer⁶⁶, Ewa Talarek⁶⁷, Julian W Tang^{68

69

70}, Kelvin To⁷¹, Dat Tran⁷², Timothy M Uyeki⁶, Wendy Vaudry⁷³, Tjasa Vidmar⁷⁴, Paul Zarogoulidis⁷⁵; PRIDE Consortium Investigators; Jonathan S Nguyen-Van-Tam¹

Collaborators, Affiliations

Collaborators

PRIDE Consortium Investigators:
Nisreen Amayiri, Robed Amin, Clarissa Baez, Carlos Bantar, Jing Bao, Mazen Mahmoud Barhoush, Ariful Basher, Julie Bettinger, Emilio Bouza, Ilkay Bozkurt, Elvira Čeljuska-Tošev, Kenny K C Chan, Yusheng Chen, Rebecca Cox, Maria R Cuezzo, Wei Cui, Simin Dashti-Khavidaki, Bin Du, Hicham El Rhaffouli, Hernan Escobar, Agnieszka Florek-Michalska, John Gerrard, Stuart Gormley, Sandra Götberg, Matthias Hoffmann, Behnam Honarvar, Edgar Bautista, Amr Kandeel, Jianmin Hu, Christoph Kemen, Gulam Khandaker, Marian Knight, Evelyn S C Koay, Miroslav Kojic, Koichiro Kudo, Arthur Kwan, Idriss Lahlou Amine, Win Mar Kyaw, Leonard Leibovici, Hongru Li, Xiao-Li Li, Pei Liu, Tze Ping Loh, Deborough Macbeth, Magdalena Marczyńska, Fabiane Pinto Mastalir, Allison McGeer, Mohsen Moghadami, Lilian Moriconi, Pagbajabyn Nymadawa, Bulent Ozbay, Fernando P Polack, Philippe Guillaume Poliquin, Wolfgang Pöppl, Alberto Rascon Pacheco, Blaž Pečavar, Mahmudur Rahman, Elena B Sarrouf, Brunhilde Schweiger, Fang Gao Smith, Antoni Torres, Selda Hancerli Torun, C B Tripathi, Daiva Velyvyte, Diego F Viasus, Qin Yu, Kwok-Yung Yuen, Wei Zhang, Wei Zuo

Affiliations

¹ Division of Epidemiology and Public Health, University of Nottingham, Nottingham.
² School of Mathematical Sciences, University of Nottingham, Nottingham.
³ MRC Unit for Lifelong Health and Ageing, University College London.
⁴ Department of Medicine, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia.
⁵ Department of Pharmacology, Government Medical College and Sir Takhtasinhji General Hospital, Bhavnagar, India.
⁶ Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁷ University Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, Rabat, Morocco.
⁸ Santa Maria Misericordia Hospital, Udine.
⁹ Department of Infectious Diseases, University Medical Center, Ljubljana.
¹⁰ Institute of Global Health, University of Geneva, Switzerland.
¹¹ Institut de Veille Sanitaire, Saint Maurice, France.
¹² National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, University of Sydney.
¹³ Instituto Mexicano del Seguro Social.
¹⁴ Medical University of Vienna, Austria.
¹⁵ Beijing Chao-Yang Hospital, Capital Medical University.
¹⁶ Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases.
¹⁷ National Influenza Center, National Center of Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia.
¹⁸ Hospital Clinic, August Pi I Sunyer Biomedical Research Institute, University of Barcelona, CIBERES, Barcelona.
¹⁹ Victorian Infectious Diseases Service and Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, Parkville.
²⁰ Department of Pediatric Infectious Diseases, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora.
²¹ Universidade Estadual do Oeste do Paraná-UNIOESTE, Cascavel.
²² Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan.
²³ Section of Pediatric Infectious Diseases, University of Manitoba, Winnipeg.
²⁴ Department of Respiratory and Critical Care Medicine, Peking University People's Hospital.
²⁵ Pôle Femme Mère Enfant.
²⁶ Center for Clinical Investigation 1410, Institut National de la Santé et de la Recherche Médical (INSERM), Centre Hospitalier Universitaire de la Réunion, Saint Pierre.
²⁷ Unité Mixte 134 Processus Infectieux en Milieu Insulaire Tropical, Centre National de la Recherche Scientifique 9192, INSERM U1187, Institut Recherche et Développement 249, Université de la Réunion, Cyclotron Réunion-océan Indien, Sainte Clotilde, Reunion.
²⁸ Department of Clinical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
²⁹ Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid.
³⁰ Department of Infectious Disease Epidemiology, Sector for National Health Documentation and Research, Statens Serum Institut, Copenhagen, Denmark.
³¹ Section of Paediatrics, Division of Infectious Disease, Imperial College, London.
³² Department of Research in Clinical Epidemiology, Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosío Villegas, Mexico City, Mexico.
³³ Catholic Children's Hospital Wilhelmstift, Hamburg.
³⁴ Peking Union Medical College Hospital, Beijing.
³⁵ Dhaka Medical College Hospital, Bangladesh.
³⁶ Departamento de Ginecologia e Obstetrícia-UFCSPA, Preceptora da Residência Médica do Hospital Fêmina, Fêmina, Brazil.
³⁷ Gold Coast University Hospital, Gold Coast, Australia.
³⁸ Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
³⁹ National Institute of Respiratory Diseases "Emilio Coni" ANLIS "C. Malbran," Santa Fe.
⁴⁰ University Hospital for Infectious Diseases, University of Zagreb School of Medicine, Croatia.
⁴¹ Department of Obstetrics and Gynaecology, Stellenbosch University-Tygerberg, Cape Town, South Africa.
⁴² Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴³ Department of Infectious Diseases, Tan Tock Seng Hospital.
⁴⁴ Department of Pediatrics, Vanderbilt University, Nashville, Tennessee.
⁴⁵ Fundacion INFANT.
⁴⁶ National Scientific and Technical Research Council, Buenos Aires.
⁴⁷ Helsinki University Hospital, Finland.
⁴⁸ Department of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
⁴⁹ Unit of Infectious Diseases, University General Hospital of Alexandroupolis, Democritus University Thrace, Dragana.
⁵⁰ British Columbia Centre for Disease Control, Vancouver.
⁵¹ Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
⁵² Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara.
⁵³ Lithuanian University of Health Sciences, Kaunas, Lithuania.
⁵⁴ Military Medical Academy, Clinic for Infectious and Tropical Diseases, University of Defense, Belgrade, Serbia.
⁵⁵ Influenza Center, Department of Clinical Science, University of Bergen.
⁵⁶ Emergency Care Clinic, Haukeland University Hospital, Bergen, Norway.
⁵⁷ Department of Infection Control, Hospital San Martín de Paraná, Entre Ríos, Argentina.
⁵⁸ Pediatric Neurology Department, Bahçeşehir University.
⁵⁹ Respiratory and Critical Care Medicine, Institute of Inflammation and Ageing, University of Birmingham, Birmingham.
⁶⁰ Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.
⁶¹ Department of Pediatrics, Charité-University Medical Center Berlin, Berlin, Germany.
⁶² Epidemiology and Surveillance Department, Ministry of Health and Population, Cairo, Egypt.
⁶³ Critical Care Department, Hospital Joan XXIII, IISPV-URV-CIBERES, Tarragona, Spain.
⁶⁴ Department of Pulmonary Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
⁶⁵ Uniwersytet Rzeszowski, Rzeszow.
⁶⁶ Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul.
⁶⁷ Department of Children's Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
⁶⁸ Department of Respiratory Sciences, University of Leicester.
⁶⁹ University Hospitals Leicester, Leicester, United Kingdom.
⁷⁰ Molecular Diagnostic Centre, Department of Laboratory Medicine, National University Hospital, Singapore.
⁷¹ Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, China.
⁷² Acute and Communicable Disease Prevention, Public Health Division, Oregon Health Authority, Portland.
⁷³ Division of Infectious Diseases, Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Canada.
⁷⁴ General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
⁷⁵ Pulmonary Department, "G. Papanikalaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

PMID: 31314899
PMCID: PMC7313925
DOI: 10.1093/infdis/jiz152

Meta-Analysis

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Sudhir Venkatesan et al. J Infect Dis. 2020.

. 2020 Jan 14;221(3):356-366.

doi: 10.1093/infdis/jiz152.

Authors

Collaborators

PRIDE Consortium Investigators:
Nisreen Amayiri, Robed Amin, Clarissa Baez, Carlos Bantar, Jing Bao, Mazen Mahmoud Barhoush, Ariful Basher, Julie Bettinger, Emilio Bouza, Ilkay Bozkurt, Elvira Čeljuska-Tošev, Kenny K C Chan, Yusheng Chen, Rebecca Cox, Maria R Cuezzo, Wei Cui, Simin Dashti-Khavidaki, Bin Du, Hicham El Rhaffouli, Hernan Escobar, Agnieszka Florek-Michalska, John Gerrard, Stuart Gormley, Sandra Götberg, Matthias Hoffmann, Behnam Honarvar, Edgar Bautista, Amr Kandeel, Jianmin Hu, Christoph Kemen, Gulam Khandaker, Marian Knight, Evelyn S C Koay, Miroslav Kojic, Koichiro Kudo, Arthur Kwan, Idriss Lahlou Amine, Win Mar Kyaw, Leonard Leibovici, Hongru Li, Xiao-Li Li, Pei Liu, Tze Ping Loh, Deborough Macbeth, Magdalena Marczyńska, Fabiane Pinto Mastalir, Allison McGeer, Mohsen Moghadami, Lilian Moriconi, Pagbajabyn Nymadawa, Bulent Ozbay, Fernando P Polack, Philippe Guillaume Poliquin, Wolfgang Pöppl, Alberto Rascon Pacheco, Blaž Pečavar, Mahmudur Rahman, Elena B Sarrouf, Brunhilde Schweiger, Fang Gao Smith, Antoni Torres, Selda Hancerli Torun, C B Tripathi, Daiva Velyvyte, Diego F Viasus, Qin Yu, Kwok-Yung Yuen, Wei Zhang, Wei Zuo

Affiliations

¹ Division of Epidemiology and Public Health, University of Nottingham, Nottingham.
² School of Mathematical Sciences, University of Nottingham, Nottingham.
³ MRC Unit for Lifelong Health and Ageing, University College London.
⁴ Department of Medicine, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia.
⁵ Department of Pharmacology, Government Medical College and Sir Takhtasinhji General Hospital, Bhavnagar, India.
⁶ Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁷ University Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, Rabat, Morocco.
⁸ Santa Maria Misericordia Hospital, Udine.
⁹ Department of Infectious Diseases, University Medical Center, Ljubljana.
¹⁰ Institute of Global Health, University of Geneva, Switzerland.
¹¹ Institut de Veille Sanitaire, Saint Maurice, France.
¹² National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, University of Sydney.
¹³ Instituto Mexicano del Seguro Social.
¹⁴ Medical University of Vienna, Austria.
¹⁵ Beijing Chao-Yang Hospital, Capital Medical University.
¹⁶ Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases.
¹⁷ National Influenza Center, National Center of Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia.
¹⁸ Hospital Clinic, August Pi I Sunyer Biomedical Research Institute, University of Barcelona, CIBERES, Barcelona.
¹⁹ Victorian Infectious Diseases Service and Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, Parkville.
²⁰ Department of Pediatric Infectious Diseases, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora.
²¹ Universidade Estadual do Oeste do Paraná-UNIOESTE, Cascavel.
²² Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan.
²³ Section of Pediatric Infectious Diseases, University of Manitoba, Winnipeg.
²⁴ Department of Respiratory and Critical Care Medicine, Peking University People's Hospital.
²⁵ Pôle Femme Mère Enfant.
²⁶ Center for Clinical Investigation 1410, Institut National de la Santé et de la Recherche Médical (INSERM), Centre Hospitalier Universitaire de la Réunion, Saint Pierre.
²⁷ Unité Mixte 134 Processus Infectieux en Milieu Insulaire Tropical, Centre National de la Recherche Scientifique 9192, INSERM U1187, Institut Recherche et Développement 249, Université de la Réunion, Cyclotron Réunion-océan Indien, Sainte Clotilde, Reunion.
²⁸ Department of Clinical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
²⁹ Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid.
³⁰ Department of Infectious Disease Epidemiology, Sector for National Health Documentation and Research, Statens Serum Institut, Copenhagen, Denmark.
³¹ Section of Paediatrics, Division of Infectious Disease, Imperial College, London.
³² Department of Research in Clinical Epidemiology, Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosío Villegas, Mexico City, Mexico.
³³ Catholic Children's Hospital Wilhelmstift, Hamburg.
³⁴ Peking Union Medical College Hospital, Beijing.
³⁵ Dhaka Medical College Hospital, Bangladesh.
³⁶ Departamento de Ginecologia e Obstetrícia-UFCSPA, Preceptora da Residência Médica do Hospital Fêmina, Fêmina, Brazil.
³⁷ Gold Coast University Hospital, Gold Coast, Australia.
³⁸ Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
³⁹ National Institute of Respiratory Diseases "Emilio Coni" ANLIS "C. Malbran," Santa Fe.
⁴⁰ University Hospital for Infectious Diseases, University of Zagreb School of Medicine, Croatia.
⁴¹ Department of Obstetrics and Gynaecology, Stellenbosch University-Tygerberg, Cape Town, South Africa.
⁴² Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴³ Department of Infectious Diseases, Tan Tock Seng Hospital.
⁴⁴ Department of Pediatrics, Vanderbilt University, Nashville, Tennessee.
⁴⁵ Fundacion INFANT.
⁴⁶ National Scientific and Technical Research Council, Buenos Aires.
⁴⁷ Helsinki University Hospital, Finland.
⁴⁸ Department of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
⁴⁹ Unit of Infectious Diseases, University General Hospital of Alexandroupolis, Democritus University Thrace, Dragana.
⁵⁰ British Columbia Centre for Disease Control, Vancouver.
⁵¹ Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
⁵² Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara.
⁵³ Lithuanian University of Health Sciences, Kaunas, Lithuania.
⁵⁴ Military Medical Academy, Clinic for Infectious and Tropical Diseases, University of Defense, Belgrade, Serbia.
⁵⁵ Influenza Center, Department of Clinical Science, University of Bergen.
⁵⁶ Emergency Care Clinic, Haukeland University Hospital, Bergen, Norway.
⁵⁷ Department of Infection Control, Hospital San Martín de Paraná, Entre Ríos, Argentina.
⁵⁸ Pediatric Neurology Department, Bahçeşehir University.
⁵⁹ Respiratory and Critical Care Medicine, Institute of Inflammation and Ageing, University of Birmingham, Birmingham.
⁶⁰ Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.
⁶¹ Department of Pediatrics, Charité-University Medical Center Berlin, Berlin, Germany.
⁶² Epidemiology and Surveillance Department, Ministry of Health and Population, Cairo, Egypt.
⁶³ Critical Care Department, Hospital Joan XXIII, IISPV-URV-CIBERES, Tarragona, Spain.
⁶⁴ Department of Pulmonary Medicine, Medical Faculty, Yuzuncu Yil University, Van, Turkey.
⁶⁵ Uniwersytet Rzeszowski, Rzeszow.
⁶⁶ Department of Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul.
⁶⁷ Department of Children's Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
⁶⁸ Department of Respiratory Sciences, University of Leicester.
⁶⁹ University Hospitals Leicester, Leicester, United Kingdom.
⁷⁰ Molecular Diagnostic Centre, Department of Laboratory Medicine, National University Hospital, Singapore.
⁷¹ Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong Special Administrative Region, China.
⁷² Acute and Communicable Disease Prevention, Public Health Division, Oregon Health Authority, Portland.
⁷³ Division of Infectious Diseases, Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Canada.
⁷⁴ General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
⁷⁵ Pulmonary Department, "G. Papanikalaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

PMID: 31314899
PMCID: PMC7313925
DOI: 10.1093/infdis/jiz152

Abstract

Background: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear.

Methods: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded.

Results: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS.

Conclusions: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.

Keywords: IPD meta-analysis; Neuraminidase inhibitors; antivirals; length of stay; pandemic influenza.

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Figures

**Figure 1.**
Identification of the study population. A(H1N1)pdm09, 2009 pandemic influenza A(H1N1) virus; LoS, length of stay; NAI, neuraminidase inhibitor.

See this image and copyright information in PMC

Comment in

Effectiveness of the Neuraminidase Inhibitors: The Supporting Evidence Increases.
Monto AS. Monto AS. J Infect Dis. 2020 Jan 14;221(3):340-342. doi: 10.1093/infdis/jiz157. J Infect Dis. 2020. PMID: 31106811 No abstract available.

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References

1. Jefferson T, Jones MA, Doshi P, et al. . Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev 2012. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008965.pub3/... - PMC - PubMed
1. Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet 2015; 385:1729–37. - PubMed
1. Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS. Efficacy and safety of oseltamivir in children: systematic review and individual patient data meta-analysis of randomized controlled trials. Clin Infect Dis 2018; 66:1492–500. - PubMed
1. Hsu J, Santesso N, Mustafa R, et al. . Antivirals for Treatment of Influenza. Ann Intern Med 2012; 156:512. - PMC - PubMed
1. Muthuri SG, Myles PR, Venkatesan S, Leonardi-Bee J, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009–2010 Influenza A(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients. J Infect Dis 2013; 207:553–63. - PMC - PubMed

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[1] Jefferson T, Jones MA, Doshi P, et al. . Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev 2012. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008965.pub3/... - PMC - PubMed

[2] Jefferson T, Jones MA, Doshi P, et al. . Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev 2012. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008965.pub3/... - PMC - PubMed

[3] Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet 2015; 385:1729–37. - PubMed

[4] Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet 2015; 385:1729–37. - PubMed

[5] Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS. Efficacy and safety of oseltamivir in children: systematic review and individual patient data meta-analysis of randomized controlled trials. Clin Infect Dis 2018; 66:1492–500. - PubMed

[6] Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS. Efficacy and safety of oseltamivir in children: systematic review and individual patient data meta-analysis of randomized controlled trials. Clin Infect Dis 2018; 66:1492–500. - PubMed

[7] Hsu J, Santesso N, Mustafa R, et al. . Antivirals for Treatment of Influenza. Ann Intern Med 2012; 156:512. - PMC - PubMed

[8] Hsu J, Santesso N, Mustafa R, et al. . Antivirals for Treatment of Influenza. Ann Intern Med 2012; 156:512. - PMC - PubMed

[9] Muthuri SG, Myles PR, Venkatesan S, Leonardi-Bee J, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009–2010 Influenza A(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients. J Infect Dis 2013; 207:553–63. - PMC - PubMed

[10] Muthuri SG, Myles PR, Venkatesan S, Leonardi-Bee J, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009–2010 Influenza A(H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients. J Infect Dis 2013; 207:553–63. - PMC - PubMed

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Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Collaborators

Affiliations

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Authors

Collaborators

Affiliations

Abstract

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