Rodent models of respiratory control and respiratory system development-Clinical significance

Respir Physiol Neurobiol. 2019 Oct:268:103249. doi: 10.1016/j.resp.2019.06.006. Epub 2019 Jul 14.

Abstract

The newborn infant's respiratory system must rapidly adapt to extra-uterine life. Neonatal rat and mouse models have been used to investigate early development of respiratory control and reactivity in both health and disease. This review highlights several rodent models of control of breathing and respiratory system development (including pulmonary function), discusses their translational strengths and limitations, and underscores the importance of creating clinically relevant models applicable to the human infant.

Keywords: Airway hyperreactivity; Apnea; Bronchopulmonary dysplasia; Neonate; Prematurity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Animals, Newborn*
  • Infant, Premature, Diseases*
  • Lung Diseases*
  • Mice
  • Models, Animal*
  • Rats
  • Respiration Disorders*
  • Respiratory Physiological Phenomena*