Surgical outcomes in patients with epilepsy after viral encephalitis: contribution of SEEG study

BMC Neurol. 2019 Jul 17;19(1):165. doi: 10.1186/s12883-019-1396-1.

Abstract

Background: Nowadays, few surgery analysis has been reported in cases of epilepsy after viral encephalitis(VE). Herein, this study was to evaluate the efficacy of surgery and capability of stereoelectroencephalography (SEEG) in the definition of the epileptogenic zone (EZ) after VE, and also to explore the relationship between the SEEG features and the surgical outcomes.

Methods: We retrospectively analyzed 10 surgically treated patients that identified to suffer from epilepsy secondary to VE using SEEG, and investigated the SEEG features associated with surgical outcomes in these patients. Besides visual analysis, we used the epileptogenicity index (EI), a semi-quantitative and supplementary tool to evaluate the validity of SEEG in the context of VE.

Results: Among the 10 operated patients, 3 of them became completely seizure-free. The patients who got totally seizure free or significant improvement, the seizure onset was located either in the antero-mesial temporal structures or focal gyrus; patients who got worthwhile improvement or no improvement, the seizure started from multiple brain lobes. The number of electrodes classified as epileptogenic visually involved were closely correlated with EI positive onses.Anatomic areas defined and shown as EZ on MRI by visual assessment were also defined as epileptogenic by the EI in these cases.

Conclusion: Apart from exploring the surgical outcome related to epilepsy after VE, we also bring insight into the relationship between the SEEG features and surgical outcome with the application of the supplementary methods.

Keywords: Epilepsy; Epileptogenicity index (EI); Stereoelectroencephalography (SEEG); Surgical outcome; Viral encephalitis.

Publication types

  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Electrodes
  • Electroencephalography / methods*
  • Encephalitis, Viral / complications*
  • Epilepsy / surgery*
  • Epilepsy / virology
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Retrospective Studies
  • Seizures / surgery
  • Treatment Outcome
  • Young Adult