Background: Lung cancer screening is an effective measure to reduce lung cancer mortality. Currently, lung cancer screening is recommended internationally and nationally. China had launched a large-scale early diagnosis and early treatment of rural and urban lung cancer in 2009 and 2012. Yunnan Province participated in related projects in 2009 and 2014, but the results of large-scale lung cancer screening have not been reported in Yunnan Province. In this study, we participated in the National Key Public Health Program, Cancer Screening Program in Urban China and analyzed the results of lung cancer screening in 10,154 urban residents in Kunming, Yunnan Province from 2014 to 2018, and evaluated the screening effect of early diagnosis and treatment of lung cancer in urban.
Methods: A total of 31,824 people with high risk of lung cancer were evaluated with 40-74 year-old population in Kunming. A high-risk group underwent low-dose spiral computed tomography (CT) scan of the chest, and analyze the high risk rate and detection rate. A total of 150,535 questionnaires were completed in 5 years, and 31,824 people with high risk of lung cancer were evaluated.
Results: The high-risk rate was 21.14%. A total of 10,154 low-dose spiral CT screenings were performed, with a participation rate of 31.91%. The detection rate of intrapulmonary nodules was 22.28% (2,262/10,154), of which the detection rate of <5 mm solid/partial solid nodules was 11.30% (1,332/10,154) and the detection rate of <8 mm non-solid nodules was 2.20% (219/10,154). The positive nodule detection rate was 7.00% (711/10,154), the suspected lung cancer detection rate was 0.60% (59/10,154), and the lung cancer detection rate was 0.27% (27/10,154). The detection rate of the positive nodules, <8 mm non-solid nodules and suspected lung cancer in male were significantly higher than that in female, and the positive nodules, <5 mm solid nodules, suspected lung cancer and confirmed lung cancer detection rate increased with age.
Conclusions: Low-dose spiral CT is suitable for screening of high-risk populations of lung cancer, which is helpful for early detection of positive nodules and related diseases in the lungs. It is necessary to pay attention to the screening of lung cancer in people over 60 years old. Understand the lung health status of residents in Kunming. Raise awareness of lung cancer prevention and treatment among residents, and improve the rate of early diagnosis and treatment of lung cancer.
【中文题目：云南省昆明市城市居民肺癌筛查结果分析】 【中文摘要：背景与目的 肺癌筛查是降低肺癌死亡率的有效措施。目前国际及全国范围内均推荐肺癌筛查，我国于2009年、2012年分别启动了大规模的农村、城市肺癌早诊早治项目，云南省先后于2009年、2014年参与相关项目，但目前云南省尚未报道大规模肺癌筛查的研究结果。本研究通过参加国家癌症中心牵头的城市癌症早诊早治项目，分析2014年-2018年云南省昆明市10,154例城市居民肺癌筛查结果，评价城市癌症早诊早治肺癌筛查效果。方法 以云南省昆明市40岁-74岁居民为研究对象，通过防癌风险问卷调查评估出肺癌高风险31,824人，对高风险人群进行胸部低剂量螺旋计算机断层扫描（computed tomography, CT），分析肺癌的高风险率、筛查率和检出率。结果 5年完成问卷调查150,535人，评估出肺癌高危人群31,824人，高风险率21.14%，共完成胸部低剂量螺旋CT筛查10,154人，参与率31.91%。肺内结节检出率22.28%（2,262/10,154），其中<5 mm实性/部分实性结节检出率11.30%（1,332/10,154）、<8 mm非实性结节检出率2.20%（219/10,154）、阳性结节检出率7.00%（711/10,154）、疑似肺癌检出率0.60%（59/10,154），肺癌检出率0.27%（27/10,154）。男性阳性结节、<8 mm非实性结节及疑似肺癌检出率显著高于女性；阳性结节、<5 mm实性结节、疑似肺癌及确诊肺癌检出率随年龄增加而增高，60岁以上年龄组最高。结论 低剂量螺旋CT适合肺癌高危人群筛查，有助于早期发现肺内的阳性结节和相关疾病，应重视60岁以上人群肺癌的筛查工作；了解了昆明市居民的肺部健康状况，提高了居民的肺癌防治意识，提高肺癌的早诊早治率。 】 【中文关键词：肺肿瘤；肿瘤筛查；危险因素】.
Keywords: Cancer screening; Lung neoplasms; Risk factors.