In 22 girls with Ullrich-Turner-Syndrome (UTS) aged 1.3 to 17.6 years basal and LHRH-stimulated gonadotropin (Gn)-concentrations as well as spontaneous variations of Gn-secretions were measured in order to recognize age dependent changes. Basal Gn-concentrations were elevated in the 1-year old girl, showed normal values in patients whose bone age was less than 11 years and were elevated again in the group with a bone age greater than 11 years. Stimulated LH and FSH concentrations were significantly elevated in all age-groups when compared with the values of age-matched controls. Minimal and maximal Gn-concentrations during spontaneous secretion were low in patients with a bone age less than 11 years, whereas a distinct elevation could be noted in the 1-year old child and in the elder group when compared with age-matched controls. According to these findings the typical age-dependent change of Gn-secretory dynamics could also be demonstrated in children with UTS albeit on an elevated level. A bone age of 11 to 11.5 years, when serum concentrations of Gn rise in healthy girls followed by onset of puberty seems to be the biological indicator for changes of the hypothalamo-hypopituitary level also in girls with Ullrich-Turner-Syndrome.