High doses of biotin can interfere with immunoassays that use biotin-strept(avidin) technologies: Implications for individuals with biotin-responsive inherited metabolic disorders

Barry Wolf

doi:10.1016/j.ymgme.2019.07.003

High doses of biotin can interfere with immunoassays that use biotin-strept(avidin) technologies: Implications for individuals with biotin-responsive inherited metabolic disorders

Mol Genet Metab. 2019 Aug;127(4):321-324. doi: 10.1016/j.ymgme.2019.07.003. Epub 2019 Jul 9.

Author

Barry Wolf¹

Affiliation

¹ Division of Genetics, Birth Defects and Metabolism, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, 225 E. Chicago, Chicago, IL 60611, United States of America. Electronic address: barrywolf1@comcast.net.

PMID: 31320189
DOI: 10.1016/j.ymgme.2019.07.003

No abstract available

Keywords: Avidin; Biotin; Biotin interference; Biotin-responsive; Biotin-thiamine-responsive basal ganglia disease; Biotinidase deficiency; Holocarboxylase synthetase deficiency; Streptavidin.

MeSH terms

Avidin / chemistry*
Biotin / administration & dosage
Biotin / blood*
Diagnostic Errors
False Positive Reactions
Humans
Immunoassay / standards*
Metabolism, Inborn Errors / blood
Metabolism, Inborn Errors / diagnosis*
Metabolism, Inborn Errors / drug therapy

Substances

Avidin
Biotin