Acquired hemophilia A in chronic lymphocytic leukemia: A case report

Transfus Apher Sci. 2019 Aug;58(4):447-448. doi: 10.1016/j.transci.2019.04.030. Epub 2019 Jul 10.

Abstract

Acquired hemophilia A, due to spontaneous autoantibody against FVIII, is a rare hemorrhagic disorder with an incidence of about 1 per million population per year. If unrecognized and untreated, it is associated with a high morbidly and mortality rate of 8-12%. Autoantibody against coagulation factor VIII neutralizes procoagulant activity. We report herein is such a rare case of acquired hemophilia in a patient with CLL.

Keywords: Acquired hemophilia A; Chronic lymphocytic leukemia; Malignant.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoantibodies / blood*
  • Blood Coagulation Factor Inhibitors / blood*
  • Factor VIII / antagonists & inhibitors*
  • Factor VIII / metabolism
  • Female
  • Hemophilia A / blood*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood*

Substances

  • Autoantibodies
  • Blood Coagulation Factor Inhibitors
  • F8 protein, human
  • Factor VIII

Supplementary concepts

  • Factor 8 deficiency, acquired