Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma

Blood. 2019 Sep 12;134(11):860-866. doi: 10.1182/blood.2019001694. Epub 2019 Jul 18.


Chimeric antigen receptor (CAR) T cells targeting CD19 have emerged as a leading engineered T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma. The phase 1/2 clinical trials that led to US Food and Drug Administration approval excluded patients with central nervous system (CNS) involvement, due to strict eligibility criteria. Here, we report on our institutional experience with 8 secondary CNS lymphoma patients treated with commercial tisagenlecleucel. No patient experienced greater than grade 1 neurotoxicity, and no patient required tocilizumab or steroids for CAR T-cell-mediated toxicities. Biomarker analysis suggested CAR T-cell expansion, despite the absence of systemic disease, and early response assessments demonstrated activity of IV infused CAR T cells within the CNS space.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Central Nervous System Neoplasms / immunology
  • Central Nervous System Neoplasms / secondary*
  • Central Nervous System Neoplasms / therapy*
  • Female
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Lymphoma / immunology
  • Lymphoma / pathology
  • Lymphoma / therapy*
  • Male
  • Middle Aged
  • Receptors, Antigen, T-Cell / therapeutic use*
  • Retrospective Studies
  • T-Lymphocytes / immunology
  • T-Lymphocytes / transplantation
  • Treatment Outcome
  • Young Adult


  • Receptors, Antigen, T-Cell
  • tisagenlecleucel