Histiocytosis X in two infants--treated with topical nitrogen mustard

Br J Dermatol. 1979 Apr;100(4):433-8. doi: 10.1111/j.1365-2133.1979.tb01645.x.


Two infants suffering from histiocytosis X were treated successfully with a topically applied nitrogen mustard. All cutaneous symptoms disappeared completely within 2 weeks in one case while the skin improved significantly in the other. No irritation or dermatitis was experienced from the treatment. The only side-effect noted was hyperpigmentation.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Child, Preschool
  • Female
  • Histiocytosis, Langerhans-Cell / drug therapy*
  • Histiocytosis, Langerhans-Cell / pathology
  • Humans
  • Infant
  • Male
  • Mechlorethamine / administration & dosage
  • Mechlorethamine / therapeutic use*
  • Microscopy, Electron
  • Skin / ultrastructure


  • Mechlorethamine