Phase-locking patterns in a resonate and fire neural model with periodic drive

Biosystems. 2019 Oct:184:103992. doi: 10.1016/j.biosystems.2019.103992. Epub 2019 Jul 16.


In this paper we studied a resonate and fire relaxation oscillator subject to time dependent modulation to investigate phase-locking phenomena occurring in neurophysiological systems. The neural model (denoted LFHN) was obtained by linearization of the FitzHugh-Nagumo neural model near an hyperbolic fixed point and then by introducing an integrate-and-fire mechanism for spike generation. By employing specific tools to study circle maps, we showed that this system exhibits several phase-locking patterns in the presence of periodic perturbations. Moreover, both the amplitude and frequency of the modulation strongly impact its phase-locking properties. In addition, general conditions for the generation of firing activity were also obtained. In addition, it was shown that for moderate noise levels the phase-locking patterns of the LFHN persist. Moreover, in the presence of noise, the rotation number changes smoothly as the stimulation current increases. Then, the statistical properties of the firing map were investigated too. Lastly, the results obtained with the forced LFHN suggest that such neural model could be used to fit specific experimental data on the firing times of neurons.

Keywords: Firing phase map; Neural model; Noise; Phase-locking; Rotation number.

MeSH terms

  • Action Potentials / physiology*
  • Algorithms*
  • Animals
  • Computer Simulation
  • Electric Stimulation
  • Models, Neurological*
  • Nerve Net / physiology
  • Neurons / physiology*
  • Synaptic Transmission / physiology