Revisit gut microbiota and its impact on human health and disease

J Food Drug Anal. 2019 Jul;27(3):623-631. doi: 10.1016/j.jfda.2018.12.012. Epub 2019 Feb 1.


Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity.

Keywords: Disease; Gut microbiota; Human health.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arthritis / metabolism
  • Cardiovascular Diseases / metabolism
  • Depression / metabolism
  • Diabetes Mellitus / metabolism
  • Gastrointestinal Microbiome*
  • Gout / metabolism
  • Humans
  • Hypertension / metabolism
  • Infant Health*
  • Inflammatory Bowel Diseases / metabolism
  • Neoplasms / metabolism*
  • Obesity / metabolism

Grants and funding

This study was funded by the Natural Science Foundation of China (Grant No. 31871831, 31471713, 31470538); Liaoning BaiQianWan Talents Program Project, Shenyang Science and Technology Project (Grant No.17-189-9-00), Shenyang Youth Science and Technology Innovation Talent Project (Grant No. RC170212)