Hemofiltration clearance of flecainide in a patient with acute renal failure

Intensive Care Med. 1988;14(3):236-7. doi: 10.1007/BF00717997.

Abstract

Flecainide, a new antiarrhythmic drug, has been shown not no be removed to a significant extent by hemodialysis or peritoneal dialysis, in spite of a high renal clearance. Its systemic and hemofiltrate clearances, measured in a patient under continuous hemofiltration, were 402 and 19.7 ml/min respectively. The clearance ratio of less than 5% makes the contribution of hemofiltration to the elimination of flecainide clinically negligible.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / therapy*
  • Flecainide* / administration & dosage
  • Flecainide* / pharmacokinetics
  • Hemofiltration*
  • Humans
  • Male
  • Middle Aged

Substances

  • Flecainide