Material properties of human lumbar intervertebral discs across strain rates

Abstract

Background context: The use of finite element (FE) methods to study the biomechanics of the intervertebral disc (IVD) has increased over recent decades due to their ability to quantify internal stresses and strains throughout the tissue. Their accuracy is dependent upon realistic, strain-rate dependent material properties, which are challenging to acquire.

Purpose: The aim of this study was to use the inverse FE technique to characterize the material properties of human lumbar IVDs across strain rates.

Study design: A human cadaveric experimental study coupled with an inverse finite element study.

Methods: To predict the structural response of the IVD accurately, the material response of the constituent structures was required. Therefore, compressive experiments were conducted on 16 lumbar IVDs (39±19 years) to obtain the structural response. An FE model of each of these experiments was developed and then run through an inverse FE algorithm to obtain subject-specific constituent material properties, such that the structural response was accurate.

Results: Experimentally, a log-linear relationship between IVD stiffness and strain rate was observed. The material properties obtained through the subject-specific inverse FE optimization of the annulus fibrosus (AF) fiber and AF fiber ground matrix allowed a good match between the experimental and FE response. This resulted in a Young modulus of AF fibers (-MPa) to strain rate (ε˙, /s) relationship of YMAF=31.5ln(ε˙)+435.5, and the C₁₀ parameter of the Neo-Hookean material model of the AF ground matrix was found to be strain-rate independent with an average value of 0.68 MPa.

Conclusions: These material properties can be used to improve the accuracy, and therefore predictive ability of FE models of the spine that are used in a wide range of research areas and clinical applications.

Clinical significance: Finite element models can be used for many applications including investigating low back pain, spinal deformities, injury biomechanics, implant design, design of protective systems, and degenerative disc disease. The accurate material properties obtained in this study will improve the predictive ability, and therefore clinical significance of these models.

Keywords: Finite element method; Intervertebral disc; Lumbar spine; Optimization; Sensitivity; Strain rate.