[Study on the effect of in vitro cultured calculus bovis in perioperative period after H-UPPP operation]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jul;33(7):639-642. doi: 10.13201/j.issn.1001-1781.2019.07.015.
[Article in Chinese]

Abstract
in English, Chinese

Objective:TThe aim of this study is to investigate the effect of in vitro cultured Calculus Bovis on the inflammation of oropharynx and body in patients with OSA during the perioperative period of H-UPPP.Method:Eighty patients with OSA and H-UPPP indications were enrolled. The patients were divided into experimental group and control group by random number table, 40 cases in each group. The experimental group was given in vitro cultured Calculus Bovis, while the control group was not given bovine bezoar in vitro. The postoperative oropharyngeal pain, time to resume normal diet, local edema, concentration of IL-1β, IL-8 and TNF-α in saliva, and concentration of IL-1β, IL-8 and TNF-α in blood were compared between the two groups. Result:The pain of oropharynx in the experimental group was lighter than that in the control group on the 3rd, 5th and 7th day after operation (P<0.05), but there was no significant difference in the pain of oropharynx between the two groups on the 1st day after operation(P>0.05); the time of restoring normal diet in the experimental group was shorter than that in the control group (P<0.05); the edema of oropharynx in the experimental group was lighter than that in the control group on the 5th and 7th day after operation (P<0.05).The levels of IL-1β, IL-8 and TNF-α in saliva were lower than those in control group on the 3rd, 5th and 7th day after operation (P<0.05), and the levels of IL-1β, IL-8 and TNF-α in blood on the 5th and 7th day after operation were lower than those in control group (P<0.05).Conclusion:In vitro perioperative period of H-UPPP can improve the postoperative sore throat and local edema of oropharynx, shorten the time of normal diet and reduce the expression of related inflammatory factors in oropharynx and blood.

目的：探讨OSA患者H-UPPP围手术期含服体外培育牛黄对术后口咽和体内炎症反应的作用。 方法：选取确诊为OSA并符合行H-UPPP手术适应证的80例患者，采用随机数字表法将患者分成实验组和对照组，每组各40例。实验组给予体外培育牛黄含服，对照组不用。比较2组患者术后口咽部疼痛、恢复正常饮食的时间、局部水肿情况，唾液中IL-1β、IL-8和TNF-α浓度以及血液中IL-1β、IL-8、TNF-α浓度。 结果:术后第3、5、7天口咽部疼痛情况实验组优于对照组（P<0.05），而术后第1天，2组之间咽部疼痛情况差异无统计学意义；术后实验组恢复正常饮食时间较对照组缩短（P<0.05）；术后第5、7天口咽部水肿情况实验组优于对照组（P<0.05）；术后第3、5、7天唾液中的IL-1β、IL-8和TNF-α水平实验组低于对照组（P<0.05）；术后第5、7天血液中IL-1β、IL-8及TNF-α浓度实验组低于对照组（P<0.05）。 结论：H-UPPP围手术期含服体外培育牛黄能改善患者术后咽痛和口咽局部水肿，缩短正常饮食的时间，降低口咽部及血液中相关炎症因子的表达。.

Keywords: H-UPPP; in vitro cultured Calculus Bovis; postoperative pain; sleep apnea,obstructive.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Cattle
  • Cholic Acids / therapeutic use*
  • Humans
  • Inflammation / prevention & control*
  • Interleukin-1beta / analysis
  • Interleukin-8 / analysis
  • Materia Medica / therapeutic use*
  • Oropharynx / pathology*
  • Otorhinolaryngologic Surgical Procedures*
  • Postoperative Period
  • Sleep Apnea, Obstructive / surgery*
  • Tumor Necrosis Factor-alpha / analysis

Substances

  • CXCL8 protein, human
  • Cholic Acids
  • IL1B protein, human
  • Interleukin-1beta
  • Interleukin-8
  • Materia Medica
  • Tumor Necrosis Factor-alpha