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Review
. 2019 Dec;129(12):1192-1197.
doi: 10.1080/00207454.2019.1645142. Epub 2019 Sep 13.

Cdk5: A Main Culprit in Neurodegeneration

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Review

Cdk5: A Main Culprit in Neurodegeneration

Krishna Kant Gupta et al. Int J Neurosci. .

Abstract

Objectives: Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders. Methods: In this review article, we have highlighted the neurodegenerative role of CDK5 and its involvement in Amyloid precursor pathway via Beta secretase enzyme. Results:All the landmark research reports for CDK5 were considered for this review and its involvement in disrupted autophagy and hyper immune response is the key cause for neurodegeneration. Conclusion: In conclusion, the present review focus on the pathways associated with Cdk5 and its role in causing neurodegeneration.

Keywords: Alzheimer Disease; Autophagy; Cdk5; Innate immunity; Neurodegeneration.

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