Surgical treatment in patients with single and multiple gland primary hyperparathyroidism with the use of intraoperative parathyroid hormone monitoring: extensive single-center experience

Hormones (Athens). 2019 Sep;18(3):273-279. doi: 10.1007/s42000-019-00121-9. Epub 2019 Jul 22.


Purpose: To evaluate a single-center extensive experience and effectiveness in surgical treatment of primary hyperparathyroidism (pHPT) with the use of rapid intraoperative parathyroid hormone (ioPTH) monitoring in patients with single gland (SGpH) or multiple gland (MGpH) disease.

Methods: This retrospective, single-center cohort study included 214 patients with pHPT treated from January 2010 to June 2017. In total, 172 patients fulfilled the inclusion criteria having at least one preoperative localization image study and measurement of ioPTH. Statistical analysis was made by the chi-square test and Student's t tests.

Results: Of the 172 patients, 146 were women (85%) and 26 men (15%), with a mean age of 56.9 years; 153 (89%) had SGpH and 19 (11%) MGpH. The mean follow-up was 41.8 months. A total of 153 surgical procedures were performed as minimal invasive parathyroidectomy (MIP) based on a SGpH diagnosis; operative success was achieved in 150 cases (98%), according to ioPTH concentrations. The remainder (19 procedures) were performed as bilateral neck exploration (BNE) based on a MGpH diagnosis; operative success was achieved in 16 cases (84%). ioPTH correctly modified the initially planned operation in 26.3% of patients with MGpH.

Conclusions: ioPTH enables the surgical treatment of patients with pHPT with focused approaches and excellent results, as it helps the surgeon to identify cases of MGpH. ioPTH adds value to cases where preoperative imaging failed to detect the affected gland or the results are inconclusive. According to the literature, its application seems to be of marginal benefit in cases in which there are two concordant preoperative imaging studies.

Keywords: Intraoperative parathyroid hormone; Multiple gland disease; Primary hyperparathyroidism; Single gland disease; Surgical treatment.

MeSH terms

  • Adenoma / blood
  • Adenoma / surgery*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperparathyroidism, Primary / blood
  • Hyperparathyroidism, Primary / diagnosis
  • Hyperparathyroidism, Primary / surgery*
  • Male
  • Middle Aged
  • Monitoring, Intraoperative / methods*
  • Neoplasms, Multiple Primary / blood
  • Neoplasms, Multiple Primary / surgery*
  • Parathyroid Hormone / analysis
  • Parathyroid Hormone / blood*
  • Parathyroid Neoplasms / blood
  • Parathyroid Neoplasms / surgery*
  • Parathyroidectomy / methods
  • Retrospective Studies
  • Young Adult


  • Parathyroid Hormone