Leptin level decreases after treatment with the combination of Radiofrequency and Ultrasound cavitation in response to the reduction in adiposity

Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1137-1140. doi: 10.1016/j.dsx.2019.01.046. Epub 2019 Jan 23.


Background: Obesity and overweight are major public health problem. Different-strategies have been developed for body contouring including Radiofrequency(RF) and Ultrasound(US). The aim of this study was to investigate changes in serum-leptin as a potential-modulator of food/energy intake, in overweight-women receiving RF/US and diet-therapy as well as the effect of therapy on modulation of lipid-profile and body-fat-mass.

Methods: Fifty overweight-females were enrolled in current randomized-clinical-trial and randomly divided into two groups. The case group received RF/US twice a week for 5 weeks with a low calorie diet whilst the control-group received just a low calorie diet. Demographic, biochemical markers as well as serum-leptin were determined.

Results: The level of leptin was reduced from 1.29 ± 0.32 ng/ml to 1.14 ± 0.34 ng/ml in case group, before and after therapy, respectively, whilst no significant differences were observed in the serum leptin levels of subjects in the control group. The combination of RF and US decreased the leptin-level. In particular, the mean reduction of abdominal-circumference and waist-circumference was significant (P < 0.05) after therapy. This reduction was inversely correlated with LDL levels. Weight was reduced in case and control groups and in both was significant, but no statistically significant differences were detected for weight between the groups(P < 0.93).

Conclusion: Our findings demonstrated the reduction of the leptin after treatment with the combination of Radiofrequency/Ultrasound cavitation, which was associated with reduced body-fat-mass.

Keywords: Leptin; Obesity (overweight); Radiofrequency; Randomized controlled; Ultrasound cavitation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiposity / radiation effects*
  • Adult
  • Biomarkers / blood*
  • Case-Control Studies
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Leptin / blood*
  • Male
  • Obesity / blood*
  • Obesity / therapy*
  • Prognosis
  • Pulsed Radiofrequency Treatment / methods*
  • Ultrasonic Therapy / methods*


  • Biomarkers
  • Leptin