Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation

Leukemia. 2019 Nov;33(11):2758-2762. doi: 10.1038/s41375-019-0521-x. Epub 2019 Jul 23.

Authors

Nhu Nguyen¹, Kevin Oakley¹, Yufen Han¹, Mary Kwok², Gary Crouch^{1

3}, Yang Du⁴

Affiliations

¹ Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
² Hematology-Oncology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA.
³ Division of Pediatric Hematology/Oncology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. yang.du@usuhs.edu.

PMID: 31337858
DOI: 10.1038/s41375-019-0521-x

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Carrier Proteins / metabolism*
Cell Nucleus / metabolism
Cell Transformation, Neoplastic*
DNA-Binding Proteins / metabolism
Exportin 1 Protein
Gene Expression Regulation, Leukemic*
HEK293 Cells
Homeobox A10 Proteins / metabolism
Homeodomain Proteins / metabolism
Humans
Karyopherins / metabolism*
Mice
Nuclear Proteins / metabolism*
Prognosis
Proto-Oncogene Proteins c-myb / metabolism
RNA-Binding Proteins / metabolism
Receptors, Cytoplasmic and Nuclear / metabolism*
Stem Cells / cytology
Transcription Factors / metabolism
Transcription, Genetic

Substances

Carrier Proteins
DNA-Binding Proteins
Homeobox A10 Proteins
Homeodomain Proteins
Karyopherins
Nuclear Proteins
Proto-Oncogene Proteins c-myb
RNA-Binding Proteins
Receptors, Cytoplasmic and Nuclear
Transcription Factors
Exportin 1 Protein
MYB protein, human
MYBBP1A protein, human
SETBP1 protein, human
Setbp1 protein, mouse
homeobox protein HOXA9
HOXA10 protein, human
Hoxa10 protein, mouse