Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia

Leukemia. 2019 Dec;33(12):2951-2956. doi: 10.1038/s41375-019-0526-5. Epub 2019 Jul 24.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Chemokine CCL17 / genetics*
  • Chemokine CCL17 / metabolism
  • Co-Repressor Proteins / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism*
  • Models, Biological
  • Mutation
  • Protein Binding
  • Receptor, Notch1 / genetics*
  • Receptor, Notch1 / metabolism*
  • Transcriptional Activation

Substances

  • CCL17 protein, human
  • Chemokine CCL17
  • Co-Repressor Proteins
  • NOTCH1 protein, human
  • Receptor, Notch1
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex