Peliosis hepatis, nodular regenerative hyperplasia of the liver, and light-chain deposition in a patient with Waldenström's macroglobulinemia

Gastroenterology. 1988 Aug;95(2):482-6. doi: 10.1016/0016-5085(88)90508-2.


We report the case of a female patient suffering from Waldenström's macroglobulinemia with three different liver lesions: peliosis hepatis, nodular regenerative hyperplasia, and light-chain deposits within the sinusoidal walls. We hypothesize that both peliosis hepatis and nodular regenerative hyperplasia might be the consequence of a disordered intrahepatic circulation determined by light-chain deposits infiltrating the sinusoidal walls.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Female
  • Humans
  • Hyperplasia
  • Immunoglobulin Light Chains / analysis
  • Liver / pathology*
  • Liver Diseases / etiology*
  • Microscopy, Electron
  • Middle Aged
  • Peliosis Hepatis / etiology*
  • Peliosis Hepatis / pathology
  • Waldenstrom Macroglobulinemia / complications*
  • Waldenstrom Macroglobulinemia / pathology


  • Immunoglobulin Light Chains