Suicide Risk in Bipolar Disorder: A Brief Review

doi:10.3390/medicina55080403

Review

. 2019 Jul 24;55(8):403.

doi: 10.3390/medicina55080403.

Suicide Risk in Bipolar Disorder: A Brief Review

Peter Dome^{1

2}, Zoltan Rihmer^{3

4}, Xenia Gonda^{3

4

5

6}

Affiliations

¹ Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, 1125 Budapest, Hungary. dome_peter@yahoo.co.uk.
² National Institute of Psychiatry and Addictions, Laboratory for Suicide Research and Prevention, 1135 Budapest, Hungary. dome_peter@yahoo.co.uk.
³ Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, 1125 Budapest, Hungary.
⁴ National Institute of Psychiatry and Addictions, Laboratory for Suicide Research and Prevention, 1135 Budapest, Hungary.
⁵ MTA-SE Neuropsychopharmacology, Neurochemistry Research Group, Hungarian Academy of Sciences, 1089 Budapest, Hungary.
⁶ NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, 1089 Budapest, Hungary.

PMID: 31344941
PMCID: PMC6723289
DOI: 10.3390/medicina55080403

Free PMC article

Review

Suicide Risk in Bipolar Disorder: A Brief Review

Peter Dome et al. Medicina (Kaunas). 2019.

Free PMC article

. 2019 Jul 24;55(8):403.

doi: 10.3390/medicina55080403.

Authors

Peter Dome^{1

2}, Zoltan Rihmer^{3

4}, Xenia Gonda^{3

4

5

6}

Affiliations

¹ Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, 1125 Budapest, Hungary. dome_peter@yahoo.co.uk.
² National Institute of Psychiatry and Addictions, Laboratory for Suicide Research and Prevention, 1135 Budapest, Hungary. dome_peter@yahoo.co.uk.
³ Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, 1125 Budapest, Hungary.
⁴ National Institute of Psychiatry and Addictions, Laboratory for Suicide Research and Prevention, 1135 Budapest, Hungary.
⁵ MTA-SE Neuropsychopharmacology, Neurochemistry Research Group, Hungarian Academy of Sciences, 1089 Budapest, Hungary.
⁶ NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, 1089 Budapest, Hungary.

PMID: 31344941
PMCID: PMC6723289
DOI: 10.3390/medicina55080403

Abstract

Bipolar disorders (BDs) are prevalent mental health illnesses that affect about 1-5% of the total population, have a chronic course and are associated with a markedly elevated premature mortality. One of the contributors for the decreased life expectancy in BD is suicide. Accordingly, the rate of suicide among BD patients is approximately 10-30 times higher than the corresponding rate in the general population. Extant research found that up to 20% of (mostly untreated) BD subjects end their life by suicide, and 20-60% of them attempt suicide at least one in their lifetime. In our paper we briefly recapitulate the current knowledge on the epidemiological aspects of suicide in BD as well as factors associated with suicidal risk in BD. Furthermore, we also discuss concisely the possible means of suicide prevention in BD.

Keywords: bipolar disorder; mood disorders; mortality; suicidal; suicide.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Rihmer Z., Dome P. Suicide and Bipolar Disorder. In: Zarate C.A.J., Manji H.K., editors. Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy. 2nd ed. Springer; Bern, Switzerland: 2017.
1. Rihmer Z., Gonda X., Döme P. The Assessment and Management of SuicideRrisk in Bipolar Disorder. In: Carvalho A.F., Vieta E., editors. The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions. Oxford University Press; Oxford, UK: 2017.
1. Staudt Hansen P., Frahm Laursen M., Grontved S., Puggard Vogt Straszek S., Licht R.W., Nielsen R.E. Increasing mortality gap for patients diagnosed with bipolar disorder—A nationwide study with 20 years of follow-up. Bipolar Disord. 2019;21:270–275. doi: 10.1111/bdi.12684. - DOI - PubMed
1. Hayes J.F., Marston L., Walters K., King M.B., Osborn D.P.J. Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014. Br. J. Psychiatry. 2017;211:175–181. doi: 10.1192/bjp.bp.117.202606. - DOI - PMC - PubMed
1. Bauer M., Andreassen O.A., Geddes J.R., Vedel Kessing L., Lewitzka U., Schulze T.G., Vieta E. Areas of uncertainties and unmet needs in bipolar disorders: Clinical and research perspectives. Lancet Psychiatry. 2018;5:930–939. doi: 10.1016/S2215-0366(18)30253-0. - DOI - PubMed

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[1] Rihmer Z., Dome P. Suicide and Bipolar Disorder. In: Zarate C.A.J., Manji H.K., editors. Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy. 2nd ed. Springer; Bern, Switzerland: 2017.

[2] Rihmer Z., Dome P. Suicide and Bipolar Disorder. In: Zarate C.A.J., Manji H.K., editors. Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy. 2nd ed. Springer; Bern, Switzerland: 2017.

[3] Rihmer Z., Gonda X., Döme P. The Assessment and Management of SuicideRrisk in Bipolar Disorder. In: Carvalho A.F., Vieta E., editors. The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions. Oxford University Press; Oxford, UK: 2017.

[4] Rihmer Z., Gonda X., Döme P. The Assessment and Management of SuicideRrisk in Bipolar Disorder. In: Carvalho A.F., Vieta E., editors. The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions. Oxford University Press; Oxford, UK: 2017.

[5] Staudt Hansen P., Frahm Laursen M., Grontved S., Puggard Vogt Straszek S., Licht R.W., Nielsen R.E. Increasing mortality gap for patients diagnosed with bipolar disorder—A nationwide study with 20 years of follow-up. Bipolar Disord. 2019;21:270–275. doi: 10.1111/bdi.12684. - DOI - PubMed

[6] Staudt Hansen P., Frahm Laursen M., Grontved S., Puggard Vogt Straszek S., Licht R.W., Nielsen R.E. Increasing mortality gap for patients diagnosed with bipolar disorder—A nationwide study with 20 years of follow-up. Bipolar Disord. 2019;21:270–275. doi: 10.1111/bdi.12684. - DOI - PubMed

[7] Hayes J.F., Marston L., Walters K., King M.B., Osborn D.P.J. Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014. Br. J. Psychiatry. 2017;211:175–181. doi: 10.1192/bjp.bp.117.202606. - DOI - PMC - PubMed

[8] Hayes J.F., Marston L., Walters K., King M.B., Osborn D.P.J. Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014. Br. J. Psychiatry. 2017;211:175–181. doi: 10.1192/bjp.bp.117.202606. - DOI - PMC - PubMed

[9] Bauer M., Andreassen O.A., Geddes J.R., Vedel Kessing L., Lewitzka U., Schulze T.G., Vieta E. Areas of uncertainties and unmet needs in bipolar disorders: Clinical and research perspectives. Lancet Psychiatry. 2018;5:930–939. doi: 10.1016/S2215-0366(18)30253-0. - DOI - PubMed

[10] Bauer M., Andreassen O.A., Geddes J.R., Vedel Kessing L., Lewitzka U., Schulze T.G., Vieta E. Areas of uncertainties and unmet needs in bipolar disorders: Clinical and research perspectives. Lancet Psychiatry. 2018;5:930–939. doi: 10.1016/S2215-0366(18)30253-0. - DOI - PubMed

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Suicide Risk in Bipolar Disorder: A Brief Review

Affiliations

Suicide Risk in Bipolar Disorder: A Brief Review

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