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, 23 (3-4), 361-5

Food-induced Histaminosis as an Epidemiological Problem: Plasma Histamine Elevation and Haemodynamic Alterations After Oral Histamine Administration and Blockade of Diamine Oxidase (DAO)

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Food-induced Histaminosis as an Epidemiological Problem: Plasma Histamine Elevation and Haemodynamic Alterations After Oral Histamine Administration and Blockade of Diamine Oxidase (DAO)

J Sattler et al. Agents Actions.

Abstract

In a randomized controlled trial, 30 pigs were orally treated with histamine (60 mg). In addition, half of the animals underwent a specific blockade of the enzyme diamine oxidase (DAO), which is the main histamine catabolising enzyme in the intestinal tract. Only these DAO-blocked animals exhibited severe clinical symptoms (e.g. hypotension, flush, vomiting) and, in parallel, showed tremendous elevations of plasma histamine levels of up to 160 ng/ml. 3 out of 15 animals in this group died within the experimental period. In contrast, the control animals neither exhibited plasma histamine levels above 5 ng/ml nor had any clinical reactions. These results contradict the current opinion that oral histamine intake in food is not clinically relevant, especially since many commonly used drugs are DAO-inhibitors and approximately 20% of our population take these drugs. Apart from drugs, some other factors (alcohol, spoilt food etc.) can also function via a blockade of DAO as an additional risk. DAO-blockade is therefore a real epidemiological problem. Evidence is presented here for the new disease concept: Food-Induced Histaminosis.

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References

    1. Klin Wochenschr. 1982 Sep 1;60(17):896-913 - PubMed
    1. Agents Actions. 1985 Apr;16(3-4):91-4 - PubMed
    1. Food Cosmet Toxicol. 1978 Apr;16(2):157-9 - PubMed
    1. Alcohol Clin Exp Res. 1984 Mar-Apr;8(2):185-90 - PubMed
    1. Biochim Biophys Acta. 1983 Mar 31;756(2):196-203 - PubMed

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