Alterations in outer membrane proteins of Pseudomonas aeruginosa associated with selective resistance to quinolones

Antimicrob Agents Chemother. 1988 May;32(5):785-7. doi: 10.1128/AAC.32.5.785.

Abstract

Electrophoresis of outer membrane proteins in three ciprofloxacin-resistant strains of Pseudomonas aeruginosa isolated during therapy and their in vitro revertants indicated that diminution or loss of a 31- to 32-kilodalton outer membrane protein correlated with resistance in two of the three isolates. Resistance was unstable and caused no cross-resistance with other antibiotics.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Outer Membrane Proteins / analysis*
  • Cell Membrane / analysis
  • Cephalosporins / pharmacology
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Microbial
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Norfloxacin / pharmacology*
  • Penicillins / pharmacology
  • Pseudomonas aeruginosa / analysis*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / ultrastructure

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Bacterial Outer Membrane Proteins
  • Cephalosporins
  • Penicillins
  • Ciprofloxacin
  • Norfloxacin