Abstract
Electrophoresis of outer membrane proteins in three ciprofloxacin-resistant strains of Pseudomonas aeruginosa isolated during therapy and their in vitro revertants indicated that diminution or loss of a 31- to 32-kilodalton outer membrane protein correlated with resistance in two of the three isolates. Resistance was unstable and caused no cross-resistance with other antibiotics.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides
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Anti-Bacterial Agents / pharmacology
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Bacterial Outer Membrane Proteins / analysis*
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Cell Membrane / analysis
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Cephalosporins / pharmacology
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Ciprofloxacin / pharmacology*
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Drug Resistance, Microbial
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Electrophoresis, Polyacrylamide Gel
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Humans
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Norfloxacin / pharmacology*
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Penicillins / pharmacology
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Pseudomonas aeruginosa / analysis*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / ultrastructure
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Cephalosporins
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Penicillins
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Ciprofloxacin
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Norfloxacin