Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations

Mol Cell. 2019 Jul 25;75(2):203-205. doi: 10.1016/j.molcel.2019.07.003.


In this issue of Molecular Cell, Gothe, Maman et al. and Canela et al. demonstrate that type II topoisomerase (TOP2B/TOP2A)-mediated DNA breaks, and the oncogenic translocations they generate, are dependent on transcription and governed by chromatin architecture.

Publication types

  • Comment

MeSH terms

  • Chromatin
  • Chromosomes
  • DNA
  • DNA Damage
  • DNA Topoisomerases, Type II / genetics*
  • DNA-Binding Proteins / genetics*


  • Chromatin
  • DNA-Binding Proteins
  • DNA
  • DNA Topoisomerases, Type II