The regulation, functions and clinical relevance of arginine methylation

Nat Rev Mol Cell Biol. 2019 Oct;20(10):642-657. doi: 10.1038/s41580-019-0155-x. Epub 2019 Jul 26.

Abstract

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes, including transcription, RNA processing, signal transduction cascades, the DNA damage response and liquid-liquid phase separation. Recent studies have provided considerable advances in the development of experimental tools and the identification of clinically relevant PRMT inhibitors. In this review, we discuss the regulation of PRMTs, their various cellular roles and the clinical relevance of PRMT inhibitors for the therapy of neurodegenerative diseases and cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arginine / genetics
  • Arginine / metabolism*
  • Humans
  • Methylation
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Protein Processing, Post-Translational*
  • Protein-Arginine N-Methyltransferases / genetics
  • Protein-Arginine N-Methyltransferases / metabolism*
  • Signal Transduction*

Substances

  • Neoplasm Proteins
  • Arginine
  • Protein-Arginine N-Methyltransferases