Action of antiepileptic drugs on neurons

Katsuhiro Kobayashi; Fumika Endoh; Iori Ohmori; Tomoyuki Akiyama

doi:10.1016/j.braindev.2019.07.006

Action of antiepileptic drugs on neurons

Brain Dev. 2020 Jan;42(1):2-5. doi: 10.1016/j.braindev.2019.07.006. Epub 2019 Jul 24.

Authors

Katsuhiro Kobayashi¹, Fumika Endoh², Iori Ohmori³, Tomoyuki Akiyama²

Affiliations

¹ Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan. Electronic address: k_koba@md.okayama-u.ac.jp.
² Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
³ Department of Special Needs Education, Okayama University Graduate School of Education, Okayama, Japan.

PMID: 31351738
DOI: 10.1016/j.braindev.2019.07.006

Abstract

The recent development of various new antiepileptic drugs (AEDs) has provided a wide range of therapeutic strategies for epilepsy. Information regarding the mechanisms of the action of AEDs is valuable when selecting drugs for individual epilepsy patients. AEDs can be categorized as those acting at the excitatory synapse, at the inhibitory synapse, on the extrasynaptic neuronal membrane, or with multiple or miscellaneous mechanisms of action. We herein briefly summarize and illustrate the action of AEDs on neurons and related findings that are pertinent to the clinical aspect of epileptology.

Keywords: Epilepsy; GABA; Mechanisms; Seizure; Sodium channel blocker; Treatment.

Publication types

Review

MeSH terms

Animals
Anticonvulsants / pharmacology*
Humans
Neurons / drug effects*
Synapses / drug effects

Substances

Anticonvulsants