Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function

Trends Neurosci. 2019 Sep;42(9):617-630. doi: 10.1016/j.tins.2019.06.003. Epub 2019 Jul 24.


The physiological functions of astrocytes within neural circuits remain incompletely understood. There has been progress in this regard from recent work on striatal astrocytes, where detailed studies are emerging. In this review, findings on striatal astrocyte identity, form, and function, are summarized with a focus on how astrocytes regulate striatal neurons, circuits, and behavior. Specific features of striatal astrocytes are highlighted to illustrate how they may be specialized to regulate medium spiny neurons (MSNs) by responding to, and altering, excitation and inhibition. Further experiments should reveal additional mechanisms for astrocyte-neuron interactions in the striatum and potentially reveal insights into the functions of astrocytes in neural circuits more generally.

Keywords: astrocyte; basal ganglia; behavior; microcircuit; morphology; striatum.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astrocytes / physiology*
  • Corpus Striatum / physiology*
  • Humans
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Signal Transduction / physiology*