Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

doi:10.1007/s11886-019-1177-x

Review

. 2019 Jul 27;21(9):89.

doi: 10.1007/s11886-019-1177-x.

Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

M Abdullah Said¹, Yordi J van de Vegte¹, Muhammad Mobeen Zafar², M Yldau van der Ende¹, Ghazala Kaukab Raja², N Verweij^{1

3}, Pim van der Harst^{4

5}

Affiliations

¹ Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands.
² PMAS University of Arid Agriculture Rawalpindi, University Institute of Biochemistry and Biotechnology, 46000 Murree Road, Rawalpindi, Pakistan.
³ Genomics plc, Oxford, OX1 1JD, UK.
⁴ Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands. p.van.der.harst@umcg.nl.
⁵ Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands. p.van.der.harst@umcg.nl.

PMID: 31352625
PMCID: PMC6661028
DOI: 10.1007/s11886-019-1177-x

Review

Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

M Abdullah Said et al. Curr Cardiol Rep. 2019.

. 2019 Jul 27;21(9):89.

doi: 10.1007/s11886-019-1177-x.

Authors

M Abdullah Said¹, Yordi J van de Vegte¹, Muhammad Mobeen Zafar², M Yldau van der Ende¹, Ghazala Kaukab Raja², N Verweij^{1

3}, Pim van der Harst^{4

5}

Affiliations

¹ Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands.
² PMAS University of Arid Agriculture Rawalpindi, University Institute of Biochemistry and Biotechnology, 46000 Murree Road, Rawalpindi, Pakistan.
³ Genomics plc, Oxford, OX1 1JD, UK.
⁴ Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands. p.van.der.harst@umcg.nl.
⁵ Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands. p.van.der.harst@umcg.nl.

PMID: 31352625
PMCID: PMC6661028
DOI: 10.1007/s11886-019-1177-x

Abstract

Purpose of the review: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.

Recent findings: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.

Keywords: Coronary artery disease; Genetic lifestyle interactions; Genetic risk scores; Genetics; Genome-wide association studies; Lifestyle.

PubMed Disclaimer

Conflict of interest statement

M. Abdullah Said, Yordi J. van de Vegte, Muhammad Mobeen Zafar, M. Yldau van der Ende, Ghazala Kaukab Raja, N. Verweij, and P. van der Harst declare that they have no conflict of interest.

Figures

**Fig. 1**
Combined genetic and lifestyle risks increase the risk of coronary artery disease. The risk of coronary artery disease (CAD) in individuals with low or high genetic risk is higher amongst individuals with poor lifestyle compared to a healthy lifestyle. Compared with individuals with low genetic risk, individuals with high genetic risk start off at higher risks of CAD, with the highest risks of CAD amongst individuals with poor lifestyle and high genetic risk

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1. Said MA, Verweij N, van der Harst P. Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK biobank study. JAMA Cardiol. 2018;3(8):693–702. - PMC - PubMed
1. Porta M, Last JM. A dictionary of public health [Internet]. Vol. 1. Oxford University Press; 2018.
1. de Waure C, Lauret G-J, Ricciardi W, Ferket B, Teijink J, Spronk S, Myriam Hunink MG. Lifestyle interventions in patients with coronary heart disease. Am J Prev Med. 2013;45(2):207–216. - PubMed
1. Reid RD, McDonnell LA, Riley DL, Mark AE, Mosca L, Beaton L, et al. Effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease: a randomized trial. CMAJ. 2014;186(1):23–30. - PMC - PubMed

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[3] Said MA, Verweij N, van der Harst P. Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK biobank study. JAMA Cardiol. 2018;3(8):693–702. - PMC - PubMed

[4] Said MA, Verweij N, van der Harst P. Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK biobank study. JAMA Cardiol. 2018;3(8):693–702. - PMC - PubMed

[5] Porta M, Last JM. A dictionary of public health [Internet]. Vol. 1. Oxford University Press; 2018.

[6] Porta M, Last JM. A dictionary of public health [Internet]. Vol. 1. Oxford University Press; 2018.

[7] de Waure C, Lauret G-J, Ricciardi W, Ferket B, Teijink J, Spronk S, Myriam Hunink MG. Lifestyle interventions in patients with coronary heart disease. Am J Prev Med. 2013;45(2):207–216. - PubMed

[8] de Waure C, Lauret G-J, Ricciardi W, Ferket B, Teijink J, Spronk S, Myriam Hunink MG. Lifestyle interventions in patients with coronary heart disease. Am J Prev Med. 2013;45(2):207–216. - PubMed

[9] Reid RD, McDonnell LA, Riley DL, Mark AE, Mosca L, Beaton L, et al. Effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease: a randomized trial. CMAJ. 2014;186(1):23–30. - PMC - PubMed

[10] Reid RD, McDonnell LA, Riley DL, Mark AE, Mosca L, Beaton L, et al. Effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease: a randomized trial. CMAJ. 2014;186(1):23–30. - PMC - PubMed

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Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

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Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

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