Abstract
We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.
MeSH terms
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Animals
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Bacillus Phages / genetics
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Base Sequence
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Cattle
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Click Chemistry
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DNA / blood
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DNA / chemical synthesis
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DNA / chemistry*
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DNA / radiation effects
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry*
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Drug Carriers / radiation effects
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Fluoresceins / chemistry*
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Fluorescence
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Fluorescent Dyes / chemistry*
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Nanostructures / chemistry*
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Nanostructures / radiation effects
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Nucleic Acid Conformation
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RNA / blood
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RNA / chemical synthesis
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RNA / chemistry*
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RNA / radiation effects
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Ultraviolet Rays
Substances
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Drug Carriers
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Fluoresceins
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Fluorescent Dyes
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RNA
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DNA