Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

Chem Commun (Camb). 2019 Aug 13;55(66):9765-9768. doi: 10.1039/c9cc02524c.


Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

MeSH terms

  • Acrylamides / pharmacology*
  • Biofilms / drug effects
  • Chromobacterium / drug effects*
  • Chromobacterium / physiology
  • Quorum Sensing / drug effects*


  • Acrylamides
  • N-isopropylacrylamide