Virulence of Brucella: Bacterial Growth and Decline in Mice

Ann Rech Vet. 1988;19(1):65-7.


Virulence may be expressed by a bacterial count in selected tissue of an animal host inoculated and autopsied in specified conditions. Time courses of splenic infection in DBA/2 mice intravenously challenged with (1) the virulent reference Brucella abortus strain 544 or with (2) the low virulent vaccinal B abortus strain 19 evidenced a one hundred times higher initial growth of the vaccine strain, followed by a steadily decrease that contrasts with the plateau phase of the virulent strain. Thus, in vivo phases of growth and decline behave independently in which immune mechanisms involved may differ.

MeSH terms

  • Animals
  • Brucella abortus / pathogenicity*
  • Mice
  • Mice, Inbred DBA
  • Virulence