Objective: To understand the mortality and influencing factors on injecting drug users (IDUs) with HIV/AIDS, in Guizhou province, 1996-2015. Methods: A retrospective cohort study was conducted on IDUs with HIV/AIDS that were reported through national comprehensive HIV/AIDS information system, in Guizhou province during 1996-2015. Cox proportional hazard regression model was used to analyze the influencing factors on the mortality of HIV/AIDS. Results: A total of 3 958 cases of IDUs with HIV/AIDS were recruited in this study, with all-cause mortality rate of 44.01% (1 742/3 958) and total mortality rate of 7.80/100 person-years, respectively. The median survival time between diagnosis and death was 8.08 years. Mortality rate was 3.57/100 person-years in the group receiving antiretroviral therapy (ART). The mortality appeared to be 4.08/100 person-years in the group who were on methadone maintenance treatment (MMT). Data from the multiple regression analysis indicated that factors of gender, ethnicity, age when HIV/AIDS diagnosis was made, CD(4)(+)T lymphocyte (CD(4)) count at the first testing, ART and MMT were significantly associated with deaths among these people. The risk of death in females was 0.82 times (95%CI: 0.69-0.98) higher than that in males. The risk of deaths among the ethnic minority subjects was 1.39 times (95%CI: 1.21-1.60) higher than that of the Hans. The risk of death appeared to be 2.44 times higher (95%CI: 1.07-5.56) in the over-50-year of age group than in the <20 year-old group, when HIV/AIDS was diagnosed for the first time. The risk of death in CD(4) ≥500/μl group in the first time was 0.27 times (95%CI: 0.22-0.32) more than CD(4) <200/μl group in the firs time. The risk of death in cases who were treated with ART or MMT was 2.83 times (95%CI: 2.45-3.26) and 1.35 times (95%CI: 1.15-1.59) higher than those who did not receive any treatment, respectively. Conclusion: Higher risks on death seemed to be related to the following factors: being male, older age at the time of diagnosis, lower CD(4) at diagnosis, not on ART or MMT among the IDUs with HIV/AIDS in Guizhou province, between 1996-2015.
目的： 了解贵州省注射吸毒人群中HIV/AIDS死亡情况及其影响因素，为降低HIV/AIDS死亡率提供参考依据。 方法： 采用回顾性队列研究方法，以我国艾滋病防治基本信息系统中1996－2015年贵州省注射吸毒人群HIV/AIDS为研究对象，应用Cox比例风险回归模型分析其死亡的影响因素。 结果： 共有3 958例注射吸毒HIV/AIDS纳入分析，全死因的死亡比例为44.01%（1 742/3 958），总死亡率为7.80/100人年，生存时间M=8.08年；抗病毒治疗（ART）组死亡率为3.57/100人年，美沙酮维持治疗（MMT）组死亡率为4.08/100人年。多因素Cox回归分析结果显示，研究对象的死亡与性别、民族、确认HIV阳性时年龄、确认HIV阳性后首次CD(4)(+)T淋巴细胞计数（CD(4)）、ART和MMT有关；女性的死亡风险是男性的0.82倍（95%CI：0.69~0.98）；少数民族的死亡风险是汉族的1.39倍（95%CI：1.21~1.60）；确认HIV阳性时年龄≥50岁的死亡风险是<20岁的2.44倍（95%CI：1.07~5.56）；确认HIV阳性后首次CD(4)≥500个/μl组的死亡风险是CD(4)<200个/μl组的0.27倍（95%CI：0.22~0.32）；未参加ART的死亡风险是参加者的2.83倍（95%CI：2.45~3.26）；未参加MMT的死亡风险是参加者的1.35倍（95%CI：1.15~1.59）。 结论： 1996－2015年贵州省注射吸毒人群HIV/AIDS中，男性、确认HIV阳性时年龄较大者、确认HIV阳性后首次CD(4)较低、未参加ART和MMT的病例，死亡风险较高。.
Keywords: HIV/AIDS; Influencing factors; Injecting drug users; Mortality.